Tab1 protein and DNA coding therefor

Details Tab1 protein and DNA coding therefor Tab1 protein and DNA coding therefor

1998-08-31

1999-11-23

Degen, Nancy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6, 435471, 435440, 435455, 435243, 435325, 4353201, 536 231, 536 232, 536 243, 536 235, C12P 2100, C07H 2104, C12N 1511, C12N 1585

Patent

active

059898623

ABSTRACT:
TAB1 protein having activity which activates factor TAK1 in the TGF-.beta. signaling pathway, and having the amino acid sequence shown in FIG. 1.

REFERENCES:
Shibuya, et al., "Is AMK-1 a Transfer Molecule Involved in TGF-.beta. Signal Transduction," 68th Meeting Of Japanese Society (Sep. 15-18, 1995; Summary Published Jul. 25, 1995 Sendai, Japan).
Nishida, et al,. "Signaling Pathways and Functions of the MAP Kinase Superfamily," 54th Meeting Of Japanese Cancer Association, (Oct. 3-5, 1995 Kyoto, Japan).
Irie, et al., "A Novel Member of MAPKK, TAK1, May Function As A Mediator In TGF-.beta. Signal Transduction," 18th Meeting Of Japanese Molecular Biochemistry Society S21-4 and 2E11, Dec. 6-9, 1995 Nagoya, Japan.
Yamaguchi, et al, et al., "Identification of a Member of the MAPKK Family as a Potential Mediator of TGF-.beta. Signal Transduction," Science 270: 2008-11 (1995).
Shibuya, et al., "TAB1: An Activator of the TAK1 MAPKK in TGF-.beta. Signal Transduction," Science 272: 1179-82 (1996).

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