T1R taste receptors and genes encoding same

Details T1R taste receptors and genes encoding same T1R taste receptors and genes encoding same

2007-07-10

2007-07-10

Andres, Janet L. (Department: 1649)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S007210, C435S069100, C435S252300, C435S325000, C436S501000, C530S300000, C530S350000, C514S002600

Reexamination Certificate

active

10035045

ABSTRACT:
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

REFERENCES:
patent: 2003/0036089 (2003-02-01), Wei et al.
patent: WO 95/08627 (1995-03-01), None
patent: WO 00/06593 (2000-02-01), None
patent: WO 2002/064631 (2002-08-01), None
Hoon et al., Cell 96(541-551), Feb. 19, 1999.
Krautwurst et al. Cell 95(917-926)1998.
Alexander et al., Proc. Natl. Acad. Sci. 89(3352-3356)1992.
Bowie et al., 1990, Science 247:1306-1310.
Mark A. Hoon, et al., “Putative Mammalian Taste Receptors: A Class of Taste-Specific GPCRs with Distinct Topograhic Selectivity”, Cell, vol. 96, pp. 541-551, Feb. 19, 1999—XP-000922524.
Xiaodong Li, et al. “Human Receptors for Sweet and Umami Taste”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, vol. 99, No. 7, Apr. 2, 2002, pp. 4692-4696—XP002254830.
R.H. Waterston, “Direct Submission”, Genome Sequencing Center, Apr. 21, 2000—XP-002262036.
Elliot Adler, et al. “A Novel Family of Mammalian Taste Receptors”, Cell, vol. 100, pp. 693-702, Mar. 17, 2000—XP-000982304.
Montmayeur, J-P., et al., “A Candidate Taste Receptor Gene Near a Sweet Taste Locus,” Nature Neuroscience, May 2001, pp. 492-498, vol. 4, No. 5, Nature America, Inc., US.
Kitagawa M., et al., “Molecular Genetic Identification of a Candidate Receptor Gene for Sweet Taste,” Biochemical and Biophysical Research Communications, Apr. 27, 2001, pp. 236-242, vol. 283, No. 1, Academic Press, San Diego, California, US.
Max Marianna, et al., “Tas1r3, Encoding a New Candidate Taste Receptor, is Allelic to the Sweet Responsiveness Locus Sac,” Nature Genetics, May 2001, pp. 58-63, vol. 28, No. 1, Nature America, New York, US.
Sainz E., et al., “Identification of a Novel Member of the T1R Family of Putative Taste Receptors,” Journal of Neurochemistry, May 2001, pp. 896-903, vol. 77, No. 3, New York, NY, US.
Johnson C., et al., “The Effect of the Sweetness Inhibitor 2(4-methoxyphenoxy) Propanoic Acid (Sodium Salt) (Na-PMP) on the Taste of Bitter-sweet Stimuli,” Chemical Sense, Aug. 1994, pp. 349-358, vol. 19, No. 4. Oxford, UK.

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