Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-05-17
2005-05-17
Fredma, Jeffrey (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C435S455000, C536S023100, C536S023500, C530S350000
Reexamination Certificate
active
06893842
ABSTRACT:
The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.
REFERENCES:
patent: 5475021 (1995-12-01), Marnett et al.
patent: 20020009772 (2002-01-01), Snutch
patent: WO 9807447 (1998-02-01), None
patent: WO 9838301 (1998-03-01), None
patent: WO 9929847 (1999-06-01), None
Chemin et al Physiol. 540(Pt 1):3-14, 2002.*
Murbartian et al FEBS Lett. 528(1-3):272-8, 2002.*
Ngo, in The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 and 492-495, 1994).*
Birkhauser Boston: Boston, MA, pp. 433 and 492-495, 1994). Rudinger (in Peptide Hormones, Parsons (ed.), University Park Press: Baltimore, MD, pp. 1-7, 1976).*
PTO sequnce search report regarding SEQ ID NO.:2, conducted 2004.*
PTO sequnce search report regarding SEQ ID NO.:4, conducted 2004.*
New England Peptide Inc. FAQ May 2004.*
Jung-Ha Lee, et al. (1999) “Cloning and Expression of a Novel Member of the Low Voltage-Activated T-Type Calcium Channel Family,”J. Neurosci, 19:1912-1921.
Amer, S. And Myerson, B., “Opioids in Neuropathic Pain,” Pain Digest 3:15-22 (1993).
Browne et al., “Ethosuximide in the Treatment of Absence (Petit Mal) Seizures,”Neurology 25:515-524 (1975).
Campbell et al., “Clinical Trial of Carbazepine (Tegretol) in Trigeminal Neuralgia,”J. Neurol. Neurosurg. Psychiatry 29:265-267 (1966).
Coulter et al., “Characterization of Ethousuxmide Reduction of Low-Threshold Calcium Current in Thalamic Neurons,”Annals of Neurology 25(6):582-593 (1989).
Coulter et al., “Specific Petit Mal Anticonvulsants Reduce Calcium Currents in Thalamic Neurons,”Neuroscience Letters 98:74-78 (1989).
Cribbs et al., “Cloning and Characterization of 1H From Human Heart, a Member of the T-Type Ca2+Channel Gene Family,”Circ. Res. 83:103-109 (1998).
Ertel, S.I. and Ertel, E.A., “Low-Voltage-Active T-Type Ca2+Channels,”Trends Pharmacol Sci. 18:37-42 (1997).
Hunter et al., “The Effect of Novel Anti-Epileptic Drugs in Rat Experimental Models of Acute and Chronic Pain,”European Journal of Pharmacology 324:153-160 (1997).
Killian, J.M. and Fromm, G.H., “Carbamazepine in the Treatment of Neuralgia-Use and Side Effects,”Arch. Neurol. 19:129-136 (1968).
Lenz, Fredrick A., Central Pain: Current Treatments, Future Prospects,Neuropathic Pain: Progress and Prospects, Jun. 4-6 p. 17 (1998).
Max et al.“Association of Pain Relief with Drug Side Effects in Postherpetic Neuralgia: A Single-Dose Study of Clonidine, Codeine, Ibuprofen, and Placebo,”Clin. Pharmacol. Ther. 43:363-371 (1988).
McQuay et al., “Anticonvulsant Drugs for Management of Pain: A Systematic Review,”Br. Med. J. 311:1047-1052 (1995).
Perez-Reyes, E., and Schneider, T., “Molecular Biology of Calcium Channels,”Kidney International 48:1111-1124 (1995).
Perez-Reyes et al., “Molecular Characterization of a Neuronal Low-Voltage-Activated T-Type Calcium Channel,”Nature 391:896-900 (1998).
Scroggs, R.S., and Fox, A.P., “Calcium Current Variation Between Acutely Isolated Adult Rat Dorsal Root Ganglion Neurons of Different Size,”J. Of Physiology 445:639-658 (1992).
Suzuki,S., and Rogawski, M.A., “T-Type Calcium Channels Mediate the Transition Between Tonic and Phasic Firing in Thalamic Neurons,”Proc. Natl. Acad. Sci. USA 86:7228-7232 (1989).
Swerdlow, M., “Anticonvulsant Drugs and Chronic Pain,”Clinical Neuropharmacology7(1):51-82 (1984).
Todorovic, S.L., and Lingle, C.J., “Pharmacological Properties of T-Type CA2+Current in Adult Rat Sensory Neurons: Effects of Anticonvulsant and Anesthetic Agents,”J. Neurophysiol 79(1):240-252 (1998).
Upton, N., “Mechanisms of Action of New Antiepileptic Drugs: Rational Design and Serendipitous Finding,”Trends Pharmacol Sci. 15:456-463 (1994).
White et al., “Transient Low-Threshold Ca2+Current Triggers Burst Firing Through an Afterdepolarizing Potential in an Adult Mammalian Neuron,”Proc. Natl. Acad. Sci. USA 86:6802-6806 (1989).
Lee et al., Gen. Bank Accession No. AF086827, Bethesda, MD. Mar. 4, 1999.
Dzhura et al., “Characterization of Hypothalamic Low-Voltage-Activated Ca Channels Based On Their Functional Expression in Xenopus Oocytes,”Neurosciencevol. 70, No 3; 729-738 (1996).
Mittman et al., “Structure and Alternative Splicing of the Gene Encoding α1l, A Human Brain T Calcium Channel α1lSubunit,”Neuroscience Letters269:121-124 (1999).
Dietrich Paul Shartzer
McGivern Joseph Gerrard
Fredma Jeffrey
Green Grant D.
Kaushal Sumesh
Syntex (U.S.A.) LLC
LandOfFree
T-type calcium channel variants; compositions thereof; and uses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with T-type calcium channel variants; compositions thereof; and uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T-type calcium channel variants; compositions thereof; and uses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3408402