T. thermophila group I introns that cleave amide bonds

Details T. thermophila group I introns that cleave amide bonds T. thermophila group I introns that cleave amide bonds

1994-07-01

1997-01-21

Leguyader, John L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 9131, 4351721, 536 231, 536 232, C12Q 168, C12H 1510

Patent

active

055958737

ABSTRACT:
The present invention relates to nucleic acid enzymes or enzymatic RNA molecules that are capable of cleaving a variety of bonds, including phosphodiester bonds and amide bonds, in a variety of substrates. Thus, the disclosed enzymatic RNA molecules are capable of functioning as nucleases and/or peptidases. The present invention also relates to compositions containing the disclosed enzymatic RNA molecule and to methods of making, selecting, and using such enzymes and compositions.

REFERENCES:
Bartel and Szostak, Science 261:1411-1418 (1993).
Beaudry and Joyce, Biochemistry 29: 6534 (1990).
Beaudry and Joyce, Science 257:635-641 (1992).
Burke, Gene 73:273-294 (1988).
Cadwell and Joyce, in PCR Methods and Applications 2: 28-33 (1992).
Cadwell and Joyce, in PCR Methods and Applications 3 (Suppl.): s136-s140 (1994).
Cech, Science 236:1532-1539 (1987).
Herschlag and Cech, Nature 344: 405-409 (1990).
Herschlag & Cech, Biochemistry 29:10159-10171 (1990).
Inoue et al., J. Mol. Biol. 189: 143-165 (1986).
Joyce et al., Nucl. Acids Res. 15: 9825 (1987).
Joyce and Inoue, Nucleic Acid Res. 17: 711-722 (1989).
Joyce et al., Nucleic Acid Res. 17: 7879 (1989).
Joyce, Gene 82: 83 (1989).
Joyce, in Molecular Biology of RNA: UCLA Symposia on Molecular and Cellular Biology, T. R. Cech (ed.), Liss, NY, 1989, pp. 361-371.
Joyce, in Antisense RNA and DNA, J. A. H. Murray (ed.), Wiley-Liss, NY, 1992, pp. 353-372.
Piccirilli, et al., Science 256: 1420-1424 (1992).
Lehman and Joyce, Nature 361: 182-185 (1993).
Robertson and Joyce, Nature 344: 467 (1990).
Sugimoto et al., Nucleic Acids Res. 17:355-371 (1989).
Tsang and Joyce, Biochemistry 33: 5966-5973 (1994).
Wang and Cech, Science 256: 526-529 (1992).
Zaug et al., Nature 324: 429-433 (1986).
Zaug et al., Science 231: 470-475 (1986).

Affiliated with

Also associated with

Rating

T. thermophila group I introns that cleave amide bonds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with T. thermophila group I introns that cleave amide bonds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T. thermophila group I introns that cleave amide bonds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2323343