t-PA with growth factor domain substitutions

Details t-PA with growth factor domain substitutions t-PA with growth factor domain substitutions

1991-10-15

1995-04-04

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4351723, 435212, C12N 964, C12N 1500, C12N 950

Patent

active

054037344

ABSTRACT:
A plasminogen activator comprising a growth factor domain, a kringle domain and a serine protease domain is disclosed. The growth factor domain contains a plurality of substitutions of substantially consecutive amino acids as compared to the growth factor domain of native t-PA, the substitutions resulting in an increase in plasma half-life.

REFERENCES:
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Gray et al., Nature, vol. 303, pp. 722-725 (1983).
Foster et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 4766-4770, (1984).
Hagen et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 2412-2416 (1986).
Beebe, Throwb. Res. 46: 245-254 (1987).
Hajjar et al., J. Clin. Invest. 80: 1712-1719 (1987).
Beebe et al., Blood 74: 2034-2037 (1989).
Fuchs, Blood 65: 539-544 (1985).
Blasi et al., J. Cell. Biol. 104: 801 (1987).
Webster's II new Riverside University Dictionary, p. 1129, Houghton Mifflin Co., Boston, Mass. 1984.

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