t-PA solution of high concentration and use of the solution in h

Details t-PA solution of high concentration and use of the solution in h t-PA solution of high concentration and use of the solution in h

1988-06-03

1991-11-26

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 9463, 424 9464, 435212, 435215, 435236, A61K 37547, A61K 3754, C12N 964, C12N 972

Patent

active

050681060

ABSTRACT:
In the preparation of parenteral solutions for the therapy and prophylaxis of thromboses and embolisms, because of the poor solubility of t-PA hitherto either the infusion of very large volumes has been necessary, or else a solution with a low volume and a high t-PA concentration has been prepared at the expense of setting up a non-physiologically low pH of 2 to 5.
Hence, the present invention relates to a process for the preparation of a solution of high concentration of a protein having plasminogen activator activity, where an increase in stability and solubility is achieved by adding at least two substances from the group of D- and/or L-amino acids, their salts, derivatives or homologs. This invention also relates to a process for the pasteurization of a protein solution having t-PA activity, and to a t-PA-containing solution prepared by the claimed process, and to the use of this solution as a fibrinolytic in human and veterinary medicine.

REFERENCES:
patent: 4258030 (1981-03-01), Sasaki et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4568544 (1986-02-01), Hasegawa et al.
Ranby et al, Progress in Fibrinolysis, vol. 5 (1981), pp. 233-235.

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