T m leveling compositions

Details T m leveling compositions T m leveling compositions

2005-04-19

2008-05-06

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S024330, C435S006120

Reexamination Certificate

active

07368549

ABSTRACT:
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.

REFERENCES:
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4351760 (1982-09-01), Khanna et al.
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4868105 (1989-09-01), Urdea et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5177196 (1993-01-01), Meyer, Jr. et al.
patent: 5210015 (1993-05-01), Gelfand et al.
patent: 5419966 (1995-05-01), Reed et al.
patent: 5449767 (1995-09-01), Ward et al.
patent: 5484908 (1996-01-01), Froehler et al.
patent: 5492806 (1996-02-01), Drmanac et al.
patent: 5512667 (1996-04-01), Reed et al.
patent: 5525464 (1996-06-01), Drmanac et al.
patent: 5556749 (1996-09-01), Mitsuhashi et al.
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5585481 (1996-12-01), Arnold, Jr. et al.
patent: 5594121 (1997-01-01), Froehler et al.
patent: 5645985 (1997-07-01), Froehler et al.
patent: 5696251 (1997-12-01), Arnold, Jr. et al.
patent: 5736626 (1998-04-01), Mullah et al.
patent: 5801155 (1998-09-01), Kutyavin et al.
patent: 5824796 (1998-10-01), Petrie et al.
patent: 5849482 (1998-12-01), Meyer, Jr. et al.
patent: 5942610 (1999-08-01), Nelson et al.
patent: 6127121 (2000-10-01), Meyer, Jr. et al.
patent: 6312894 (2001-11-01), Hedgpeth et al.
patent: 6339147 (2002-01-01), Lukhtanov et al.
patent: 2006/0069242 (2006-03-01), Masure et al.
patent: WO 84/03285 (1984-08-01), None
patent: WO 90/03370 (1990-05-01), None
patent: WO 92/10588 (1992-08-01), None
patent: WO 96/17957 (1996-08-01), None
patent: WO 96/32496 (1996-10-01), None
patent: WO 97/46313 (1997-12-01), None
patent: WO 98/49180 (1998-11-01), None
patent: WO 99/37085 (1999-07-01), None
patent: WO 99/51621 (1999-10-01), None
patent: WO 99/51775 (1999-10-01), None
patent: WO 00/06771 (2000-02-01), None
patent: WO 02/12263 (2002-02-01), None
U.S. Appl. No. 09/457,616, filed Dec. 8, 1999, Reed et al.
U.S. Appl. No. 10/302,607, filed Nov. 22, 2002, Charles R. Petrie et al.
Allawi, Hatim T. et al, “Thermodynamics and NMR of Internal G-T Mismatches in DNA”,Biochemistry. vol. 36: 10581-10595 (1997).
Balow, Guity et al., “Biophysical and antisense properties of oligodeoxynucleotides containing 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2′-deoxyadenosines”,Nucleic Acids Research, vol. 26, No. 14:3350-3357 (1998).
Beaucage, Serge L. et al., “Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach”,Tetrahedron Report Number 309vol. 48, No. 12:2223-2311 (1992), Pub. in Great Britain.
Blake, R.D. et al, “Statistical mechanical simulation of polymeric DNA melting with MELTSIM”,Bioinformatics, vol. 15, No. 5, 370-5 (1999).
Bolli, Martin et al, “Watson-Crick base-pairing properties of bicyclo-DNA”,Nucleic Acids Research, vol. 24, No. 23:4660-4667 (1996)—Oxford University Press.
Capaldi, Stephen et al., “Signal amplification through nucleotide extension and excision on a dendritic DNA platform”,Nucleic Acids Research, vol. 28, No. 7:E21 (2000)—Oxford University Press.
Chen, Jer-Kang et al., “Synthesis of oligodeoxyribonucleotide N3′→P5′ phosphoramidates”Nucleic Acids Research, vol. 23, No. 14:2661-2668 (1995)—Oxford University Press.
Draper, David E. et al. “A Method for Linking Fluorescent Labels to Polynucleotides: Application to Studies of Ribosome—Ribonucleic Acid Interations”,Biochemistryvol. 19:1774-1781 (1980)—American Chemical Society.
Eisen, Michael B., et al., “DNA Arrays for Analysis of Gene Expression”,Methods in Enzymology, vol. 303:179-205 (1999)—Academic Press.
Flanagan, W. Michael et al, “Elucidation of gene function using C-5 propyne antisense oligonucleotides”,Nature Biotechnology, vol. 14:1139-1145 (1996).
Giesen, Ursula et al, “A formula for thermal stability (Tm) prediction of PNA/DNA duplexes”Nucleic Acids Research, vol. 26, No. 21:5004-5006 (1998)—Oxford University Press.
Guetens, G. et al., “Nanotechnology in bio/clinical analysis”, Journal of ChromatographyB. Biomed. Sci. Appl.vol. 739:139-150 (2000)—Elsevier Science B.V.
Hacia, Joseph G. et al., “Mutational analysis using oligonucleotide microarrays”,J. Mol. Genet., vol. 36:730-736 (1999).
Hall, Jeff G. et al, “Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction”,PNASvol. 97, No. 15:8272-77 (2000).
Heid. Christian A. et al. “Real Time Quatitative PCR”,Genome Researchvol. 6:986-994 (1996)—Cold Spring Harbor Laboratory Press.
Livak, Kenneth J. et al., “Oligonucleotides with Fluorescent Dyes at Opposite Ends Provide a Quenched Probe Systm Useful for Detecting PCR Product and Nucleic Acid Hybridization”,PCR Methods and. Applicationsvol. 4:357-362 (1995)—Cold Spring Harbor Laboratory Press.
Lohkov, S. G., “Thermodynamic and spectral properties of DNA miniduplexes with the terminal G-A mispairs and 3′ or 5′ dangling bases”,FEBS Lettersvol. 420:134-138 (1997)—Federation of European Biochemical Societies.
Lyamichev, Victor et al., “Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes”,Nature Biotechnology, vol. 17:292-296 (1999).
Mueller, James D. et al, “Self-sustained sequence replication (3SR): an alternative to PCR”,Histochem. Cell Biol., vol. 108:431-437 (1997)—Springer-Verlag.
Nielsen, Peter E. et al., “Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide”Science, vol. 254:1497-1500 (1991).
Owczarzy, Richard et al, “Predicting Sequence-Dependent Melting Stability of Short Duplex DNA Oligomers”,Biopolymers “Sequence-Dependent Melting Stability”, vol. 44:217-239 (1997)—John Wiley & Sons, Inc. 1998.
Palissa, Manfred et al., Reduktion geschützler 2′-Chlor-2′-desoxydinucleotide mit Tri-n-butylzinnhydrid,Z. Chem., vol. 27:216 (1987).
Pastinen, Tom et al., “A System for Specific, High-throughput Genotyping by Allele-specific Primer Extension on Microarrays”,Genome Research, vol. 10:1031-42 (2000)—Cold Spring Harbor Laboratory Press.
Ramzaeva, Natalya et al., “123. 7-Deazaguanine DNA: Oligonucleotides with Hydrophobic or Cationic Side Chains”,Helvetic Chimica. Acta, vol. 80:1809-1822 (1997).
Reddy, B.S. Praveen et al., “Synthetic DNA minor groove-binding drugs*”,Pharmacolpgy&Therapeutics, vol. 84:1-111 (1999)—Elsevier Science Inc.
Schütz, Ekkehard et al., “Spreadsheet Software for Thermodynamic Melting Point Prediction of Oligonucleotide Hybridization with and without Mismatches”BioTechniques, vol. 27, No. 6:1218-22 (1999).
Seela, Frank et al., “Synthesis of oligonucleotides containing pyrazolo [3,4-d]-pyrimidines: The influence of 7-substituted 8-aza-7-deazaadenines on the duplex structure and stability”,J. Chem. Soc. Perkin Trans., vol. I:479-488 (1999).
Seela, Frank et al., “The N8-(2′-deoxyribofuranoside) of 8-aza-7deazaadenine: a universal nucleoside forming specific hydrogen bonds with the four canonical DNA constituents”,Nucleic Acids Research, vol. 28, No. 17:3224-3232 (2000)—Oxford Univeristy Press.
Singh, Sanjay et al, “LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition”,Chem. Comm., 455-456 (1998).
Smith, C.C. et al, “Modified adenovirus penton base protein (UTARVE) as a non-replicating vector for delivery of antisense oligonucleotides with antiviral and/or antineoplastic activity&

Affiliated with

Also associated with

Rating

T m leveling compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with T m leveling compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T m leveling compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3985388