Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 8 to 10 amino acid residues in defined sequence
Patent
1992-01-23
1993-05-11
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
8 to 10 amino acid residues in defined sequence
435 5, 930221, C07K 706
Patent
active
052101819
ABSTRACT:
The instant invention relates to monoclonal antibodies, the cell lines producing those antibodies, the peptides that comprise the epitopes of those antibodies and assays using those antibodies and peptides for the detection of HIV-1 and HIV-2 gene products. In particular, the antibodies react with the p24/p26 capsid protein, the nonapeptide that comprises an HIV-1/HIV-2 conserved epitope is disclosed and a capture ELISA using a combination of three monoclonal antibodies that can detect simultaneously HIV-1 and HIV-2 is disclosed.
REFERENCES:
patent: 5081226 (1992-01-01), Berzofsky
Beachey, Edwin et al. "Protective and Non-Protective peptides of Chemically Syntaziol Peptides of the NH.sub.2 -terminal Region of Type 6 Streptococcal M Protein" J. of Immuno 136, No. 6, Mar. 15, 1986 pp. 2287-2292.
Meyehans, Andrews et al., "Temporal Fluctuations in HIV Ovasispecies in vivo to not Reflected by Sequential HIV Isolarlins" Cell, 58, Sep. 8, 1984, p. 908.
Niedrig et al., "Monoclonal Antibodies Directer against Human Immunodeficiency Virus (HIV) gag Proteins with Specificity for Conserved Epitoxes in HIV-1, HIV-2 and Semiam Immunodeficiency Virus" J. Gen. Virol. 69 (1988) 2109-2114.
Ratner et al., "Complete nucleotide sequence of the AIDS virus, HTLV-III" Nature 313 (1985) 277-284.
Dowbenko et al., "Bacterial expression of the acquired immuno-deficiency syndrome retrovirus p. 24 gag protein and its use as a diagnostic reagent," Proc. Natl. Acad. Sci USA, 82 (1985) 7748-52.
Alizon et al., "Genetic Variahelitz of the AIDS Virus: Nucleotide Sequence Analysis of Two Isolates from African Patients" Cell (1986) 63-74.
Gryader et al, "Genome organization and transactivation of the human immunodeficiency virus type 2," Nature (1987) 662-669.
Chokrobarti et al, "Sequence of semian immunodeficiency virus from macopue and its relationship to the other human and semian viruses" Nature (1987) 543-7.
Marcus-Sekura et al, "Reactivity of an HIV gag gene polypeptide expressed in E. coli with sera from AIDS patients and monoclonal antibodies to gag" Biochim Biophys. Acta (1988) 213-223.
Hirsch et al, "An African private lentivirus (SIV.sub.sm) closely related to HIV-2" Nature (1989) 389-392.
Butman Bryan T.
Venetta Thomas M.
Akzo N.V.
Blackstone William M.
Bobrowicz Donna
Dubrule Chris
Nucker Christine M.
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