Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1984-06-13
1989-10-17
Wiseman, Thomas G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
435 68, 435 70, 4351723, 435320, 536 27, 935 12, 935 18, 935 48, C07K 1300, C12P 2100, C12N 1500, C07H 1512
Patent
active
048748455
ABSTRACT:
Disclosed is a heterodimeric T lymphocytes receptor subunit. The subunit consists of variable, joining, constant, transmembrane, and cytoplasmic regions.
The structure, amino acid, and nucleotide sequence of the lymphocyte receptor subunit were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes.
T cell receptor subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.
REFERENCES:
Collins et al., Nature, 314:723-724, 1985.
Yanagi et al., Proc. National Acad. Sci. (USA) 82:3430-34, 1985.
Murre et al., Nature, 316:549-552, 1985.
Lefranc et al., Nature, 316:464-466, 1985.
Marx, 1983, "Likely T-Cell Receptor Gene Cloned", Science, v. 224, pp. 1278-1279.
Berzofsky, 1983, "Promising Clues to Reception Genes and Molecules", Immunology Today, v. 4, 299-301.
Kappler, John, Ralph Kubo, Kathryn Haskins, Janice White and Phillipe Marrack, "The Mouse T Cell Receptor: Comparison of MHC-Restricted Receptors on Two T Cell Hybridomas", Cell, 34, 727-737 ( Oct. 1983).
Oreste Acuto et al., "The Human T Cell Receptor: Appearance in Ontogeny and Biochemical Relationship of .alpha. and .beta. Subunits on IL-2 Dependent Clones and T Cell Tumors", Cell, 34, 717-726 (Oct. 1983).
Eisen Herman N.
Kranz David M.
Saito Haruo
Tonegawa Susumu
Massachusetts Institute of Technology
Mays Thomas D.
Wiseman Thomas G.
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