Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-04-12
1992-09-15
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 9, 435 30, 435 34, 4352402, 435243, C12Q 104, C12Q 124, C12N 506, G01N 33569
Patent
active
051477840
ABSTRACT:
Methodology is provided for identifying the presence of human T-lymphocyte progenitor cells. Human thymus tissue is depleted of endogenous lymphold cells, repopulated with a human cellular composition which is HLA mismatched with the thymus tissue and implanted into a vascularizable site in an immunocompromised host. After at least about 2 weeks, the tissue may be assayed for the presence of the HLA mismatched T-lymphocytes as indicative of human T-lymphocyte progenitors in this cellular composition.
REFERENCES:
J. Kurtzberg et al., Proc. Natl. Acad. SCI. U.S.A., 86, 7575-7579, 1989.
R. Scullay et al., Immunol. Rev., 104, 81-120, 1988.
Rowland Bertram I.
Saunders David
Systemix, Inc.
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