T-lymphocyte progenitor cell assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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424 9, 435 30, 435 34, 4352402, 435243, C12Q 104, C12Q 124, C12N 506, G01N 33569

Patent

active

051477840

ABSTRACT:
Methodology is provided for identifying the presence of human T-lymphocyte progenitor cells. Human thymus tissue is depleted of endogenous lymphold cells, repopulated with a human cellular composition which is HLA mismatched with the thymus tissue and implanted into a vascularizable site in an immunocompromised host. After at least about 2 weeks, the tissue may be assayed for the presence of the HLA mismatched T-lymphocytes as indicative of human T-lymphocyte progenitors in this cellular composition.

REFERENCES:
J. Kurtzberg et al., Proc. Natl. Acad. SCI. U.S.A., 86, 7575-7579, 1989.
R. Scullay et al., Immunol. Rev., 104, 81-120, 1988.

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