T-cell suppressor protein

Details T-cell suppressor protein T-cell suppressor protein

1990-04-09

1992-12-15

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530351, 435 691, A61K 1300

Patent

active

051718413

ABSTRACT:
The invention provides a purified protein substantially free of other human proteins, having an amino acid sequence sufficiently duplicative of the sequence: ##STR1## such that the protein is capable of selectively suppressing the immune function of T-helper cells.

REFERENCES:
patent: 4665032 (1987-05-01), Laurence
Aune et al., Proc. Natl. Acad. Sci. USA, 78(8) 5099-5103 (1981).
"Soluble Immunosuppressor Factors in Human Cancer", Guidi et al., Clinical Immunology Newsletter, 124-127 (9:8 1988).
"The Immune System in AIDS", Laurence, Scientific American, vol. 253, pp. 84-93, (Dec. 1985).
"Immunoregulatory Lymphokines of T Hybridomas from AIDS Patients: Constitutive and Inducible Suppressor Factors", Laurence et al., Science, vol. 225, pp. 66-69, (Jul. 6, 1984).
"DNA Cloning, vol. I, a practical approach", Glover, ed., IRL Press, Oxford/Washington, D.C. (1985).
"Soluble Suppressor Factors in Patients with Acquired Immune Deficiency Syndrome and Its Prodrome", Journal of Clinical Investigation, vol. 72, pp. 2072-2081 (Dec. 1983).
"Establishment of a human T-cell hybrid line with suppressive activity", Grillot-Courvalin et al., Nature, vol. 292, pp. 844-845 (Aug. 27, 1981).

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