Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Reexamination Certificate
2002-07-01
2009-06-30
Ewoldt, G. R (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
Reexamination Certificate
active
07553939
ABSTRACT:
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
REFERENCES:
patent: 5721351 (1998-02-01), Levinson
patent: 5986059 (1999-11-01), Shanafelt et al.
patent: 6204371 (2001-03-01), Levinson
patent: 6288218 (2001-09-01), Levinson
patent: 7060458 (2006-06-01), Doucette-Stamm et al.
patent: WO 97/44460 (1997-11-01), None
patent: WO9938881 (1999-08-01), None
patent: WO 02/081517 (2002-10-01), None
Meyers et al., 2005, Trends in Mol. Med. vol. 11: 362-369.
Monney, et al., (2002),Nature, 415:536-541.
Feigelstock, D. et al. “The Human Homolog of HAVcr-1 Codes for a Hepatitis A Virus Cellular Receptor,”J. Virology, Aug. 1998, vol. 72, No. 8, pp. 6621-6628.
Carninci, P. et al. “Normalization and Substraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes,”Genome Res. 2000, vol. 10, No. 10, pp. 1617-1630.
Ichimura, T. et al. “Kidney Injury Molecule-1 (KIM-1), a Putative Epithilial Cell Adhesion Molecule Containing a Novel Immunoglobin Domain, Is Up-regulated in Renal Cells After Injury,”J. Biol. Chem., Feb. 1998, vol. 273, No. 7, pp. 4135-4142.
Xa, J.Q. et al. “Immune Response and Airway Reactivity in Wild and IL-4 Knockout Mice Exposed to Latex Allergens,”Int. Arch. Aller. Immunol., Jan. 1999, vol. 118, No. 1, pp. 23-29.
McIntire et al., “Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family,” Nature Immunol. 2(12):1109-1116 (2001).
Rosenwasser and Borish, “Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies,” Amer. J. Respir. Crit. Care Med. 156(4):S152-S155 (1997).
Shakhov et al., “Smuckler/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling,”Eur. J. Immun. 34(2):494-503 (2004).
GenBank Accession No. XM—011327 NCBI Annotation Project, submitted Jul. 31, 2002 National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.
GenBank Accession No. BAB55044 Isogai and Otsuki, “NEDO human cDNA sequencing project” submitted May 10, 2001.
GenBank Accession No. AI506340 Marra et al. “The WashU-NCI Mouse EST Project”1999.
GenBank Accession No. Q8CIC7 Strausberg et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”Proc. Natl. Acad. Sci. U.S.A. 99(26), 16899-16903 (2002).
GenBank Accession No. Q96H15 Gerhard et al. “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”Genome Res. 14 (10B), 2121-2127 (2004).
Dekruyff Rosemarie
Freeman Gordon J.
Kuchroo Vijay
McIntire Jennifer Jones
Umetsu Dale T.
Ballard Spahr Andrews & Ingersoll LLP
Dana-Farber Cancer Institute Inc.
Ewoldt G. R
Juedes Amy E
The Board of Trustees of the Leland Stanford Junior University
LandOfFree
T cell regulatory genes and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with T cell regulatory genes and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T cell regulatory genes and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4141900