T-cell receptorγ alternate reading frame protein,...

Details T-cell receptorγ alternate reading frame protein,... T-cell receptorγ alternate reading frame protein,...

2006-05-30

2006-05-30

Rawlings, Stephen L. (Department: 1643)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Cancer cell or component thereof

C536S023400, C536S023500, C514S015800, C514S016700, C424S185100, C424S192100, C424S093100, C435S320100, C435S372300

Reexamination Certificate

active

07052703

ABSTRACT:
This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein (“TARP”) expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.

REFERENCES:
patent: 2003/0108963 (2003-06-01), Schlegel et al.
patent: WO 01/04309 (2001-01-01), None
Cheng W-S, et al. Endocrinology. 2003; 144 (8): 3433-40.
Maeda H, et al. J. Biol. Chem. Jan. 4, 2002; 279 (23): 24561-8.
Lu J, et al. Cancer Res. Oct. 15, 2002; 62 (20): 5807-12.
Bodey B, et al. Anticancer Res. 2000: 20: 2665-76.
Splitler LE. Cancer Biotherapy, 1995; 10 (1): 1-3.
Ezzell C. J NIH Res. Jan. 1995; 7: 46-9.
Burgess WH, et al. J Cell Biol Nov. 1990; 111 (5 Pt 1): 2129-38.
Bowie JU, et al. Science Mar. 16, 1990; 247 (4948): 1306-10.
Lazar E, et al. Mol Cell Biol Mar. 1988; 8 (3): 1247-52.
Skolnick J, et al. Trends Biotechnol Jan. 2000; 18 (1): 34-9.
Ward AM. Developmental Oncol. 1985; 21: 90-106.
Gura T. Science. 1997; 278: 1041-2.
Tockman MS, et al. Cancer Res. 1992; 52 (Suppl.): 2711s-2718s.
Wolfgang CD, et al. Proc Natl Acad Sci USA. Aug. 15, 2000; 97 (17): 9437-42.
Wolfgang CD, et al. Cancer Res. Nov. 15, 2001; 61: 8122-6.
Greenspan NS, et al. Nature Biotech. 1999; 7: 936-7.
Boon T. Advances in Cancer Research. 1992; 58: 177-210.
Critchfield GC. Disease Markers. 1999; 15: 108-11.
Sidransky D. Science. Nov. 7, 1997; 278: 1054-8.
Oh et al., “Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells,”Cancer Res.64(7):2610-2618, 2004 (abstract only).
Wolfgang et al., “T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin,”Cancer Res.61(22):8122-8126, 2001 (abstract only).
GenBank Accession No. AAG29337.
GenBank Accession No. AI557112.
GenBank Accession No. CAA51166.
GenBank Accession No. M27334.
GenBank Accession No. X72500.
Krangel et al., GenBank Accession No. M16768, Jan. 14, 1995.
Wolfgang et al., “TARP: A nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor γ chain locus,”Proc. Natl. Acad. Sci USA, 97(17):9437-9442 (2000).
Oh et al.,Cancer Research64:2610-2618, 2004.
Wolfgang et al.,Cancer Research61:8122-8126, 2001.
GENBANK® Accession No. AAG29337.
GENBANK® Accession No. AI557112.
GENBANK® Accession No. CAA51166.
GENBANK® Accession No. M27334.
GENBANK® Accession No. X72500.
Essand et al., “High expression of a specific T-cell receptor γ transcript in epithelial cells of the prostate,”Proc. Natl. Acad. Sci. USA, vol. 96, pp. 9287-9292 (1999).
Davodeau et al., “Secretion of Disulfide-linked Human T-cell Receptor γδ Heterodimers,”The Journal of Biological Chemistry, vol. 268, No. 21, pp. 15455-15460 (1993).
Yoshikai, et al., “Repertoire of the human T cell gamma genes: high frequency of nonfunctional transcripts in thymus and mature T cells,”Eur. J. Immunol.vol. 17, No. 1, pp. 119-126 (1987) (Embl. Database Entry HSTCRGAA4, Accession No. M27334).
Huang et al., “Prostate cancer expression profiling by cDNA sequencing analysis,”Genomics, vol. 59, No. 2, pp. 178-186 (1999) (EMEST Database Entry AI557112, Accession No. AI557112).
Hawkins et al., “PEDB: the Prostate Expression Database,”Nucleic Acids Research, vol. 27, No. 1, pp. 204-208 (1999).
Vasmatzis et al., “Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis,”Proc. Natl. Acad. Sci. USA, vol. 95, pp. 300-304 (1998).

Affiliated with

Also associated with

Rating

T-cell receptorγ alternate reading frame protein,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with T-cell receptorγ alternate reading frame protein,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T-cell receptorγ alternate reading frame protein,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3577510