T cell receptor ligands and methods of using same

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

06900024

ABSTRACT:
The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.

REFERENCES:
patent: 5260422 (1993-11-01), Clark et al.
patent: 5284935 (1994-02-01), Clark et al.
patent: 5837477 (1998-11-01), Germain et al.
patent: 5948409 (1999-09-01), Germain et al.
patent: 5958712 (1999-09-01), Germain et al.
Adorini et al., “In vivo competition between self peptides and foreign antigens in T-cell activation,”Nature, 334, 623-625 (1988).
Adorini et al., “Competition for antigen presentation in living cells involves exchange of peptides bound by Class Il MHC molecules,”Nature, 342, 800-803 (1989).
Adorini et al., “Exogenous Peptides Compete for the Presentation of Endogenous Antigens to Major Histocompatibility Complex Class II-restricted T Cells,”J. Exp. Med., 174, 945-948 (1991).
Alexander et al., “Functional Consequences of Engagment of the T Cell Receptor by Low Affinity Ligands,”J. Immunol., 150, 1-7 (1993).
Ashwell et al., “Functional Analysis of the Interaction of the Antigen-specific T Cell Receptor With Its Ligands,”J. Immunol., 136, 757-768 (1986).
De Magistris et al., “Antigen Analog-Major Histocompatibility Complexes Act As Antagonists of the T Cell Receptor,”Cell, 68, 625-634 (1992).
Matis et al., “Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and la molecules,”Proc. Natl. Acad. Sci. USA, 80, 6019-6023 (1983).
Metcalf et al., “In Vitro Tolerance Induction of Neonatal Murine B Cells,”J. Exp. Med., 143, 1327-1340 (1976).
Mueller et al., “An Accessory Cell-derived Costimulatory Signal Acts Independently of Protein Kinase C Activation to Allow T Cell Proliferation and Prevent the Induction of Unresponsiveness,”J. Immunol., 142, 2617-2628 (1989).
Mueller et al., “Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signaling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy,:”Ann. Rev. Immunol., 7, 445-480 (1989).
Mueller et al., An Intracellular Calcium Increase and Protein Kinase C Activation Fail to Initiate T Cell Proliferation in the Absence of a Costimulatory Signal,:J. Immunol., 144, 3701-3709 (1990).
Murray et al., “Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype,”Eur. J. Immunol., 22, 559-565 (1992).
Otten et al., Split Anergy in a CD8+ T Cell: Receptor-Dependent Cytolysis in the Absence of Interleukin-2 Production,:Science, 251, 1228-1231 (1991).
Quill et al., “Stimulation of Normal Inducer T Cell Clones with Antigen Presented by Purified La Molecules in Planar Lipid Membranes: Specific Induction of a Long-lived State of Proliferative Nonresponsiveness,”J. Immunol., 138, 3704-3712 (1987).
Rock et al., “Selective Modification of a Private I-a Allostimulating Determinant(s) Upon Association of Antigen with an Antigen-presenting Cell,”J. Exp. Med., 159, 1238-1252 (1984).
Rothband et al., “Interactions Between Immunogenic Peptides and MHC Proteins,”Ann. Rev. Immunol., 9, 527-565 (1991).
Soloway et al., “Regulation of the Immune Response to Peptide Antigens: Differential Induction of Immediate-type Hypersensitivity and T Cell Proliferation Due to Changes in Either Peptide Structure or Major Histocompatibility Complex Haplotype,”J. Exp. Med., 174, 847-856 (1991).
Townsend et al., “Antigen Recognition by Class I-restricted T Lymphocytes,”Ann. Rev. Immunol., 7, 601-624 (1989).
Eckels et al. “Peptide-mediated modulation of T-cell allorecognition,”Proc. Natl. Acad. Sci. USA, 85, 8191-8195 (1988).
Evavold et al., “Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand,”Science, 252, 1308-1310 (1991).
Flering et al., “Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor,”Genes Dev., 4, 1823-1834 (1990).
Harding et al., “CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones,”Nature, 356, 607-609 (1992).
Lelouneur et al., “T-cell and basophil activation through the cytoplasmic tail of T-cell receptor H family proteins,”Proc. Natl. Acad. Sci. USA, 88, 8905-8909 (1991).
Maryanski et al., “Synthetic Peptides as Antigens and Competitors in Recognition by H-2-restricted Cytolytic T Cells Specific for HLA,”J. Exp. Med., 167, 1391-1405 (1988).
Wegener et al., “The T Cell Receptor/CD3 Complex Is Composed of at Least Two Autonomous Transduction Modules,”Cell, 68, 83-95 (1992).
L. Racioppi et al., “The Molecular Basis of Class II MHC Allelic Control of T Cell Responses,”Jour. Immunol., 147, 3718-3727 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

T cell receptor ligands and methods of using same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with T cell receptor ligands and methods of using same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T cell receptor ligands and methods of using same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3411513

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.