Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2003-06-05
2010-06-29
Ewoldt, G. R (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
active
07744893
ABSTRACT:
The present invention relates generally to the field of treating and monitoring multiple sclerosis by utilizing T-cell receptors peptides. In particular, nucleic acids and peptide sequences of T-cell receptors found in a population of MS patients are provided, along with compositions comprising such TCR peptides for use in, e.g., vaccines.
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Godkins, A.J., et al. J. Immunol. 2001;166:6720-6727.
Hong J., et al., A Common TCR V-D-J Sequence in Vβ13.1 T Cells Recognizing an Immunodominant Peptide of Myelin Basic Protein in Multiple Sclerosis, Journal of Immunology, 1999;163:3530-8.
Hong, J., et al., Reactivity and Regulatory Properties of Human Anti-Idiotypic Antibodies Induced by T Cell Vaccination, Journal of Immunology, 2000;165:6858-64.
Kozovska, M., et al., T Cell Recognition Motifs of an Immunodominant Peptide of Myelin Basic Protein in Patients with Multiple Sclerosis: Structural Requirements and Clinical Implications, Eur. J. Immunol., 1998;28:1894-1901.
Martin, R., et al., A Myelin Basic Protein Peptide is Recognized by Cytotoxic T Cells in the Context of Four HLA-DR Types Associated with Multiple Sclerosis, Journal of Experimental Medicine, 1991;173:19-24.
Arnold & Porter LLP
Baylor College of Medicine
Ewoldt G. R
Lorenz Todd
Opexa Pharmaceuticals, Inc.
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