Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1994-04-29
1998-11-24
Spector, Lorraine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
514 16, 514 14, 514 12, 514 2, 435 693, 435 697, 435 691, 435325, 435361, 4352523, 530300, 530324, 530326, 530328, 530350, 530402, 530403, C07K 14725, C12N 1512, C12N 1562
Patent
active
058403043
ABSTRACT:
Oligonucleotide sequences are provided coding for T-cell-specific antigen receptors or fragments thereof. The oligonucleotide sequences can be used as probes for detecting helper and cytotoxic T-cells, preparing and isolating DNA sequences encoding for the receptor polypeptide, and in constructions for expression of receptor polypeptides or fragments thereof. In addition, processing signals from the receptor subunits can be employed in conjunction with modified wild type oligonucleotide sequences or non-wild type oligonucleotide sequences.
REFERENCES:
patent: 4550086 (1985-10-01), Reinherz et al.
patent: 4713332 (1987-12-01), Mak
patent: 4874845 (1989-10-01), Saito et al.
patent: 4923799 (1990-05-01), Mak
patent: 5316925 (1994-05-01), Davis et al.
Z. Eshar et al., Nature 286(5770):270-272, Jun. 17, 1980.
H. Binz et al., J. Exp. Med. 154(5):1261-78, Nov. 1, 1981.
A. Boned et al., J. Immunol. Meth. 55(1):99-105, Nov. 26, 1982.
Kronenberg et al., "Helper and Killer T Cell do not Express B Cell Immunoglobulin Joining and Constant Region Genes" Journal of Experimental Medicine 152 (1980) pp. 1745-1761.
Kronenberg et al., "Three T Cell Hybridomas do not Contain Detectable Heavy Chain Variable Gene Transcripts" Journal of Experimental Medicine 158 (1983) pp. 210-227.
Allison et al., "Tumor Specific Antigen of Murine T-Lymphoma Defined With Monocolonal Antibody" Journal of Immunology 129(5) (1982) pp. 2293-2300.
Acuto et al., "The Human T Cell receptor: Appearance in Ontogeny and Biochemical Relationship of Subunits on IL-2 . . . " Cell 34 (1983) pp. 717-726.
Meuer et al., "Evidence for the T3-Associated 90K Heterodimer as the T-Cell Antigen Receptor" Nature 303 (1983) pp. 808-810.
Kappler et al., "The Mouse T Cell Receptor: Comparison of MHC-Restricted Receptors on Two T-Cell Hybridomas" Cell 34 (1983) pp. 727-737.
Hedrick et al., "The Isolation of cDNA Clones Encoding T Cell Specific Membrane Associated Proteins" Nature 308 (1984) pp. 149-153.
Yanagi et al., "A Human T Cell Specific cDNA Clone Encodes a Protein having Extensive Homology to Immunoglobulin Chains" Nature 308 (1984) p. 145.
Berzofsky, "T-Cell Activation by Antigen: Promising Clues to Reception Genes and Molecules" Immunology Today 4 (1983) pp. 299-301.
Marx, "Likely T Cell Receptor Gene Cloned" Science 221 (Sep. 1983) pp. 1278-1279.
McIntyre and Allison, "The Mouse T Cell Receptor: Structural Heterogeneity of Molecules of Normal T Cells Defined by Xenoantiserum" Cell 34 (1983) pp. 739-746.
Baker, J.J. W. et al., "The Study of Biology" Fourth Edition. The Study of Biology (1982) p. 922.
Creighton, T.E. "Proteins: Structures and Molecular Principles" W.H. Freeman and Co. (1983) pp. 93-99.
Lewin, R. Science 237 (1987) p. 1570.
Hamilton, Science 250: 1331-1332 (1990).
Acuto, et al., "Peptide Variability Exists Within .alpha. and .beta. Subunits of the T Cell Receptor For Antigen" J. Exp. Med. 158 (1983) pp. 1368-1373.
Bigler, et al., "Idiotype-Like Molecules on Cells of a Human T Cell Leukemia" J. Exp. Med. 158 (1983) pp. 1000-1005.
Haskins, et al., "The Major Histocompatibility Complex-Restricted Antigen Receptor On T Cells" J. Exp. Med. 157 (1983) pp. 1149-1169.
Hercend, et al., "Identification of a Clonally Restrictedd 90 kD Heterodimer on Two Human Cloned Natural Killer Cell Lines" J. Exp. Med 158 (1983) pp. 1547-1560.
Kappler, et al., "The Major Histocompatibility Complex-restricted Antigen Receptor on T Cells in Mouse and Man: Identification of Constant and Variable Peptides" Cell 35 (1983) pp. 295-302.
Marrack, et al., "Antigen-Specific, Major Histocompatibility Complex-Restricted T Cells Receptors" Immunological Rev. 76 (1983).
Marrack, et al., "The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells" J. Exp. Med. 158 (1983) pp. 1635-1646.
Meuer et al., "Antigen-Like Effects of Monoclonal Antibodies Directed at Receptors on Human T Cell Clones" J. Exp. Med. 158 (1983) pp. 988-993.
Meuer, et al., "Clonotypic Structures Involved in Antigen-Specific Human T Cell Function" J. Exp. Med. 157 (1983) pp. 705-719.
Reinherz, et al., "Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: Evidence for peptide variability in T-cell receptor structures" Proc. Natl. Acad. Sci. USA 80 (1983) pp. 4104-4108.
Samelson and Schwartz, "T Cell Clone-specific Alloantisera that inhibit or Stimulate Antigen-induced T Cell activation" The Journal of Immunology 131 (1983) p. 2645.
Samelson, et al., "Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid" Proc. Natl. Acad. Sci. USA 80 (1983) pp. 6972-6976.
White, et al., "Use of I Region-restricted, Antigen-specific T Cell Hybridomas to Produce Idiotypically Specific Anti-receptor Antibodies" The Journal of Immunology (1983) pp. 1033-1303.
Davis Mark M.
Hedrick Stephen M.
Bd. of Trustees of the Leland Stanford Junior University
Spector Lorraine M.
LandOfFree
T-cell receptor .beta.subunit polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with T-cell receptor .beta.subunit polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T-cell receptor .beta.subunit polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1699170