T-cell membrane protein

Details T-cell membrane protein T-cell membrane protein

1987-03-26

1989-05-30

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530327, 530326, C07K 1300, C07K 708, C07K 706

Patent

active

048352551

ABSTRACT:
A 16.7 kilodalton membrane protein which is produced in mature, but no early-stage, T cells has been discovered. The protein has four distinct amphipathic domains, each having an amino acid composition which is predictive of an alpha helical structure that would be stable in a lipid bilayer. Each of these regions is flanked by a relatively polar domain whose amino acid sequence is predictive of .beta. pleat peptide regions. An antibody specific against one of the polar domains can be used to discriminate mature T-cells in a mixed-cell sample.

REFERENCES:
Proc. Nat'l. Acad. Sci. 83 (1986), 742-746.
The Journal of Immunology 137, 2043-2049 (1986).
Brenner et al., (1987) Chemical Abstracts 106, Abstract No. 136555z.
Alonso et al., (1988) Chemical Abstracts 108, Abstract No. 107319m.
Krangel et al., (1987) Science 237:64-67.
Sutcliffe, J. G., et al., Antibodies that React with Predetermined Sites on Proteins, Science, 219:660.
Berzofsky, J. A., Intrinsic and Extrinsic Factors in Protein Antigenic Structure, Science, 229:932.
The Merck Manual of Diagnosis and Therapy, Fifteenth Edition, 1987, 1176-1181.
Alonso, M. A., et al., cDNA Cloning and Sequence of MAL, a Hydrophobic Protein Associated with Human T-Cell Differentiation, Proc. Natl, Acad. Sci., USA, 84:1997-2001.
Hedrick et al., (1984) Nature 308:149-153.

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