Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-01-11
1995-08-08
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 435 693, 935 11, 935 12, 536 231, A61K 3900, C07K 1500
Patent
active
054400171
ABSTRACT:
The present invention provides novel DNA sequences, recombinant DNA (rDNA) molecules, processes for producing novel T-cell proteins expressed in T-cell development, the novel T-cell proteins in substantially pure form and antibodies which bind to the novel proteins. More particularly, it relates to novel DNA sequences expressed in appropriate hosts and the novel T-cell proteins produced in these hosts. The present invention also provides novel transmembrane proteins in substantially pure form, rDNA molecules encoding transmembrane proteins and processes for producing the novel transmembrane proteins. The DNA sequences and recombinant DNA molecules of this invention are characterized in that they are expressed by T lymphoma cells and have at least one of the following characteristics: (1) is expressed in normal thymus, activated spleen cells, or gut associated lymphoid tissue, (2) is expressed in ovarian tissue, normal liver and/or in a stage specific manner in embryonic development and (3) encode novel transmembrane proteins having multiple membrane spanning domains.
REFERENCES:
MacCleod et al, Cancer Rese. 44:1784-1790 (1984). "A. Murne . . . System for the in vitro Development of Thymoma".
MacCleod et al, Mol. & Cell. Biol. 10(7): 3663-3674 (1980) "Activat. T Cells Express a Novel Gene on Chromo 8 . . . ".
Wilkinson et al, Developmental Biol. 141:451-455 (1990).
"A Novel Oncofetal Gene is Expressed in a Stage Specific . . . ".
Pierce et al, Cancer Research, 48: 1996-2004 (1988) "Tumors as Caricatures of the Process of Tissue Renewal".
Adler Benjamin
Lacey David L.
Nisbet T. Michael
Research Development Foundation
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