T-cell lymphocyte subset monitoring of immunologic disease

Details T-cell lymphocyte subset monitoring of immunologic disease T-cell lymphocyte subset monitoring of immunologic disease

1984-10-19

1987-06-30

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 29, 435 34, 435 7, 436501, 436543, 436546, 424 71, 424 85, C12Q 106, G01N 33566

Patent

active

046770615

ABSTRACT:
Methods and compositions are provided for determining a change in status of a multiple sclerosis victim. Particularly, the ratio of helper or suppressor T cell subsets having specific surface markers associated with proliferation is determined, where a particular ratio value is associated with a change in status.

REFERENCES:
patent: 4311686 (1982-01-01), Angers et al.
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Lanier, Lewis L. and Loken, Michael R., "Human Lymphocyte Subpopulations Identified by Using Three-color Immunofluorescence and Flow Cytometry Analysis: Correlation of Leu-2, Leu3, Leu-7, Leu-8 and Leu-11 Cell Surface Antigen Expression," J. Immunol., 132:151-156 (1984).
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Hauser, Stephen L., Reinherz, Ellis L., Hoban, Carolyn J., Schlossman, Stuart F. and Weiner, Howard L., "Immunoregulatory T-Cells and Lymphocytotoxic Antibodies in Active Multiple Sclerosis: Weekly Analysis over a Six-month Period," Annals of Neurol., 13:418-425 (1983).
Dalchau, R. and Fabre, J. W., "Studies on the Distribution Among T Lymphocytes of the High-Molecular-Weight Form of the Human Leucocyte Common Antigen," Leukocyte Typing, eds. Bernard, A., Boumsell, L. et al., p. 507, Springer-Verlag, Berlin.
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