T cell immunopotentiator

Details T cell immunopotentiator T cell immunopotentiator

1988-10-04

1990-08-21

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514885, 536 23, 536 24, 424 851, 424 852, A61K 31395, A61K 3170, C07H 19123

Patent

active

049506471

ABSTRACT:
##STR1## 6-Amino-1-(2-deoxy-.alpha.D-erythro-pentofuranosyl)imidazo [4,5-C]pyridin-4-one (also know as .alpha.-2'-deoxy-3-deazaguanosine) is non mitogenic to human peripheral blood lymphocytes; however, it displays a potent immunoenhancing activity on human T cells. This compound causes a marked increase in both phytohemagglutinin and Concanavalin A induced proliferation of T cells. When added during allogeneic mixed lymphocyte response, it also potentiates the proliferation of alloreative T cells. The compound shows no potentiating effect on B lymphocytes activated either with Staphylococcus aureus cowan or Pokeweed mitogen, suggesting that it is mainly a T cell function immunopotentiator. The compound overcomes induced immunosuppression and is able to restore depressed proliferative responses of T cells. Further it potentiates the generation of antigen-specific primary cytotoxic T lymphocytes.

REFERENCES:
patent: 3919193 (1975-11-01), Mian et al.,
patent: 4056674 (1977-11-01), Robins et al.
patent: 4780313 (1988-10-01), Koichiro et al.
Ganapathi R. Revankar et al., J. Medicinal Chemistry, vol. 27, 1389, (1984).

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