Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1990-01-08
1996-12-24
Stone, Jacqueline M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4351723, 4352402, 435 6952, 536 231, C12N 1512, C12N 1563
Patent
active
055873022
ABSTRACT:
The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.
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patent: 4745051 (1988-05-01), Smith et al.
patent: 4965195 (1990-10-01), Namen et al.
Yang et al, Blood, vol. 74, No. 6, Nov. 1, 1989, pp. 1880-1884.
Uyttenhove et al, PNAS, vol. 85, Sep. 1988, pp. 6934-6938.
Suggs et al, PNAS, vol. 78, No. 11, Nov. 1981, pp. 6613-6617.
Van Snick et al, J. Exp. Med., vol. 169, Jan. 1989, pp. 363-368.
Simpson Richard J.
Uyttenhove Catherine
Van Snick Jacques
Ludwig Institute for Cancer Research
Stone Jacqueline M.
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