T cell factors influencing B cell development

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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530412, 530417, 424 851, 514 2, 514 8, 514885, 930140, A61K 3819, C07K 1452

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056865775

ABSTRACT:
The present invention relates to an isolated protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The present invention further provides an isolated DNA molecule encoding the protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The isolated DNA molecule can be inserted as a heterologous DNA in an expression vector forming a recombinant DNA expression system for producing the protein or polypeptide. Likewise, the heterologous DNA can be incorporated in a cell to achieve this objective. The isolated protein or polypeptide of the present invention can be combined with a pharmaceutically-acceptable carrier or used alone for administration to mammals for activating production of B cells.

REFERENCES:
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Hardy et al., "Resolution and Characterization of Pro-B and Pre-Pro-B Cell Stages in Normal Mouse Bone Marrow," J. Exp. Med., 173:1213-25 (1991).
Li et al., "Regulated Expression of B Lineage Associated Genes During B Cell Differentiation in Bone Marrow and Fetal Liver," J. Exp. Med., 178:951-60 (1993).
Hirano et al. (1986) Nature vol. 326 pp. 73-76.
Rosenberg et al. (1986) Science vol. 223 pp. 1412-1415.
Neale et al. (1992) Mol. Immunol. vol. 29, No. 12, pp. 1457-1466.
Namen et al. (1988) Nature vol. 333 pp. 571-573.
Muegge et al. (1993) Science vol. 261, pp. 93-95.
Faust et al. (1993) J. Exp. Med. vol. 177, pp. 915-923.

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