Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof
Patent
1995-06-07
1999-10-19
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Allergen or component thereof
4241841, 4241851, 4241711, 435 71, 435 74, 435 792, 435 693, 514 2, 514 12, A61K 3935, A61K 39395, G01N 3353, G01N 33573
Patent
active
059685263
ABSTRACT:
The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
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Chen Xian
Evans Sean
Franzen Henry M.
Garman Richard D.
Greenstein Julia L.
Immulogic Pharamaceutical Corporation
Scheiner Laurie
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