T cell epitopes of the hepatitis B virus nucleocapsid protein

Drug – bio-affecting and body treating compositions – Lymphokine

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424 89, 530324, 530325, 530326, 530327, 530328, 530345, 530350, 530403, 530806, 530809, 530826, A61K 3900, A61K 3929, C07K 700, C07K 1500

Patent

active

051437260

ABSTRACT:
Polypeptides corresponding in amino acid residue sequence to T cell stimulating regions of the HBV nucleocapsid protein are disclosed. A method of enhancing the immunogenicity of a polypeptide immunogen comprising operatively linking the polypeptide through an amino acid residue side chain to core protein particles is also disclosed.

REFERENCES:
patent: 4818527 (1989-04-01), Thornton et al.
patent: 4882145 (1989-11-01), Thornton et al.
Clark et al., Nature, 330:381-384 (1987).
Rudinger, Peptide Hormones, Parsons (Ed.) U. Park Press, Baltimore, pp. 1-7 (1976).
Talmadge et al., 13th International Congress of Chemotherapy, Proceedings (Spitzy et al. Ed.) pp. 203/19-203/35 (1983).

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