T cell epitopes of the hepatitis B virus nucleocapsid protein

Details T cell epitopes of the hepatitis B virus nucleocapsid protein T cell epitopes of the hepatitis B virus nucleocapsid protein

1986-12-09

1989-04-04

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 530324, 530325, 530326, 530345, 530350, 530403, 530806, 530807, 530405, A61K 3900, A61K 3929, C07K 700, C07K 1500

Patent

active

048185272

ABSTRACT:
Polypeptides corresponding in amino acid residue sequence to T cell stimulating regions of the HBV nucleocapsid protein are disclosed. A method of enhancing the immunogenicity of a polypeptide immunogen comprising operatively linking the polypeptide through an amino acid residue side chain to core protein particles is also disclosed.

REFERENCES:
patent: 4474757 (1984-10-01), Arnon et al.
patent: 4584195 (1986-04-01), Schoolnik et al.
patent: 4663436 (1987-05-01), Elder et al.
patent: 4683136 (1987-07-01), Milich et al.
Milich et al., Science, vol. 234, pp. 1398-1401, (Dec. 12, 1986).
Valenzuela et al., Chemical Abstract, vol. 102, No. 216278u, (1985), (Abstract of Bio/Technology, 3(4), pp. 323-326, 1985).
Bittle et al., Nature, 298;30-33, (1982).
Wain-Hobson et al., Cell, 40:9-17, (1985).

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