T cell epitopes of ryegrass pollen allergen

Details T cell epitopes of ryegrass pollen allergen T cell epitopes of ryegrass pollen allergen

2006-09-26

2006-09-26

Schwadron, Ronald B. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

C424S185100, C424S275100, C424S276100, C514S002600, C514S012200, C514S013800, C514S014800, C514S015800, C514S016700, C514S885000, C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000, C530S370000, C530S868000

Reexamination Certificate

active

07112333

ABSTRACT:
The present invention provides isolated peptides of Lol p V, a major protein allergen of the speciesLolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bind IgE. The invention also provides modified peptides having similar or enhanced therapeutic properties or other desirable properties as the corresponding, naturally-occurring allergen or portion thereof. The invention further provides nucleic acid sequences coding for peptides of the invention. Use of the therapeutic compositions comprising one or more peptides of the invention in the manufacture of medicaments for treating sensitivity to Lol p V or an allergen immunologically related to Lol p V, or for general ryegrass sensitivity in an individual, is also provided. The invention also provides nucleic acid sequence coding for Dac g V protein allergen as well as the amino acid sequence of Dac g V protein allergen.

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