Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-15
1998-01-20
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 514 15, 514 16, 514 17, 530325, 530326, 530327, 530328, 530329, 530324, 4242751, A61K 3810, A61K 3816, A61K 3936
Patent
active
057101264
ABSTRACT:
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bind IgE. The invention also provides modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or diagnosis of sensitivity to Lol p V or an allergen immunologically related to Lol p V in an individual. Therapeutic compositions comprising one or more peptides of the invention are also provided.
REFERENCES:
Klysner, et al., "Group V allergens in grass pollens: IV. Similarities in amino acid compositions and NH.sub.2 -terminal sequences of the Group V allergens from Lolium perenne, Poa pratensis and Dactylis glomerata", Clinical and Experimental Allergy, (1992), vol. 22, pp. 491-497.
Kahan, B. 1992 Current Opinion in Immunology 4:553-560.
Perez et al 1990 J. of Biol. Chem. 265:16210-16215.
Litwin, A. 1991 Clin and Exp. Allergy 21:457-465.
Griffith Irwin J.
Kuo Mei-chang
Luqman Mohammad
Cunningham Thomas M.
Immulogic Pharmaceutical Corporation
Lubet Martha
Mandragouras Amy E.
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