T-cell epitopes

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241931, 4241841, 42419511, 42419711, 4242341, 4242411, 530350, 530324, 530325, 530326, 530327, 514 12, 514 14, 514 15, A61K 39108, C07K 708

Patent

active

059286440

ABSTRACT:
T-cell epitopes of or derived from the TraT protein of E. coli have been identified and used in the preparation of complexes with immunogens to enhance or provide immune responses to the immunogens. The complexes can be prepared directly, by chemical linkage, or as fusion proteins. In the latter context, polynucleotides encode a fusion protein which a transformed host can express. The fusion proteins may be expressed intracellularly or exported to and expressed on the surface of the transformant host.

REFERENCES:
patent: 5403586 (1995-04-01), Russell-Jones et al.
Adorini, L. et al., "Mechanisms Influencing the Immunodominance . . . ", The Journal of Experimental Medicine, vol. 168: pp. 2091-2104.
Avrameas, S. et al., "Coupling of Enzymes to Antibodies and Antigens", Scand. J. Immunol., vol. 8, (Suppl. 7) pp. 7-23 (1978).
Buus, S. et al., "A Group-specific Inhibitor of Lysosomal Cysteine Proteinases Selectively Inhibits . . . ," The Journal of Immunology, vol. 136, No. 2, pp. 452-458.
Chanh, T. C. et al., "Synthetic Peptides Homologous to HIV Transmembrane Glycoprotein Suppress Normal Human Lymphocyte Blastogenic Response", Cellular Immunol. 111, pp. 77-86 (1988.
Chouaib, S. et al., "Generation of Lymphokine-activated Killer Cells: Synergy Between Tumor Necrosis Factor and Interleukin 2", Proc. Natl. Acad. Sci. USA, vol. 85, pp. 6875-6879 (Sep. 1988).
Delisi, C. et al., "T-cell Antigenic Sites Tend to be Amphipathic Structures", Proc. Natl. Acad. Sci. USA, vol. 82, pp. 7048-7052 (Oct. 1985).
Tsai, C. M. et al., "A Sensitive Silver Stain for Detecting Lipopolysaccharides in Polyacrylamide Gels", Analytical Biochemistry 119, pp. 115-119 (1982).
Webster, C. J., "Principles of a Quantitative Assay for Bacterial Endotoxins in Blood that Uses Limulus Lysate and a Chromogenic Substrate", Journal of Clinical Microbiology, vol. 12, pp. 644-650.
Bolivar, F. et al., "Construction and Characterization of New Cloning Vehicles. II. A Multipurpose Cloning System", Gene 2, pp. 95-113.
Ogata, R. T. et al., "Nucleotide Sequence Analysis of the Complement Resistance Gene from Plasmid R100", Journal of Bacteriology, vol. 151, No. 2, pp. 819-827.
Perumal, N. B. et al., "The Product of the F Sex Factor traT Surface Exclusion Gene is a Lipoprotein", The Journal of Biological Chemistry, vol. 259, No. 9, pp. 5357-5360 (1984).
Perumal, N. B. et al., "Biochemical Characterization of the F Sex Factor traT surface Gene Product", Dissertation Abstracts International, vol. 46, No. 5, p. 160 (1985).
Sukupolvi, S. et al., "Amino Acid Alterations in a Hydrophobic Region of the TraT Protein of R6-5 Increase the Outer Membrane Permeability of Enteric Bacteria", Mol. Gen. Genet. 210, pp. 178-180 (1987).
Sukupolvi, S. et al., "Characterization of the TraT Gene and Mutants that Increase Outer Membrane Permeability from the Salmonella typhimurium virulence plasmid", Mol. Microbiol. 4(1), pp. 49-57.
Taylor, I. M. et al., "The TraT Lipoprotein as a Vehicle for the Transport of Foreign Antigenic Determinants to the Cell Surface of Escherichia coli K12: Structure-function Relationships in the TraT Protein", Mol. Microbiol. 4(8), pp. 1259-1268 (1990).
Sukupolvi, S. et al., "TraT Lipoprotein, a Plasmid-specified Mediator of Interactions Between Gram-Negative Bacteria and their Environment", Microbiological Reviews, vol. 54, No. 4, pp. 331-334 (1990).
Croft, S. et al., "TraT: A Powerful Carrier Molecule for the Stimulation of Immune Responses to Protein and Peptide Antigens", The Journal of Immunology, vol. 146, No. 3, pp. 793-798 (1991).
Islajakumari et al., J.Mol.Biol. 198; pp. 1-11 (1987).
Finlay et al., J. of Bacteriology 166(3); pp. 713-721 (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

T-cell epitopes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with T-cell epitopes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T-cell epitopes will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-875959

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.