Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1987-12-15
1991-02-19
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 724, C12Q 168, C12Q 100
Patent
active
049943693
ABSTRACT:
Nucleic acids and peptides are provided which can be used for detecting the status of functional T-lymphocytes as to stimulation and the time of stimulation. The nucleic acids and peptides may be provided by cloning and expression using recombinant techniques. These diagnoses may be used to determine whether T-cells are functional and the degree to which a T-cell population has been stimulated.
REFERENCES:
Sakaguchi et al., (1986) Embo J., 5:2139-2147.
Kronke, et al., "Sequential Expression of Genes Involved in Human T Lymphocyte Growth and Differentiation" in J. Exp. Med. (1985) 161:1593-1598.
Miyamoto, et al., "Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-.beta. Gene Regulatory Elements" in Cell (1988) 54:903-913.
Landschult, et al., "The leucine Zipper: A Hypothetical Structure Common to a class of DNA binding Proteins" in Science 240:1759-1764.
Mazrimas, et al., "A Corrected Primary Sequence for Bull Protamine" in Biochem. Biophys. Acta. (1986) 872:11-15.
O'Brien, et al., "Coding of Two Sphingolipid Activator Proteins (SAP-1 and SAP-2), by the Same Genetic Locus" in Science (1988) 241:1098-1101.
Jongstra, et al., "The Isolation and Sequence of a Novel Gene From a Human Functional T Cell Line" in J. Exp. Med., (1987) 165:601-614.
Davis Mark
Jongstra Jan
Krensky Alan M.
Schall Thomas
Burrous Beth A.
Rowland Bertram I.
Teskin Robin L.
The Board of Trustees of the Leland Stanford Jr. Univ.
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