Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-01-14
1992-08-04
Nucker, Christine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 6, 530300, 530324, 536 27, C07K 300, A61K 3702, C12Q 168, C07H 1512
Patent
active
051360225
ABSTRACT:
A polypeptide designated H400 and its encoding nucleic acid are provided as markers specific for activated human T cells. Activated T cells are detected immunochemically by monoclonal antibodies specific for H400 or its immunogenic peptides. Activated T cells are also detected by nucleic acid probes directed to messenger RNA encoding the H400 protein.
REFERENCES:
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4483920 (1984-11-01), Gillespie et al.
Kinashi, et al., 1986 "Cloning of complementary DNA encoding T-cell replacing factor . . . " Nature 324: 70-73.
Zurawski, et al., 1986 "Activation of mouse T-helper cells induces abundant preproenkephalin . . . " Nature 232: 772-775.
Angerer et al, Genetic Engineering, vol. 7, pp. 43-65 (1985).
Wolpe et al, J. Exp. Med., vol. 167, pp. 570-581 (1988).
Burd et al, J. Immunol., vol. 139, pp. 3126-3131 (1987).
White et al, J. Biol. Chem., vol. 257, pp. 8569-8572 (1982).
Southern, J. Mol. Biol. vol. 98, pp. 503-517 (1975).
Thomas, Proc. Natl. Acad. Sci., vol. 77, pp. 5201-5205 (1980).
Obaru et al, J. Biochem., vol. 99, pp. 885-894 (1986).
Brown Keith D.
Mosmann Timothy R.
Zurawski Gerard
Zurawski Sandra M.
Macevicz Stephen C.
Nucker Christine
Schering Corporation
Smith Lynette F.
LandOfFree
T cell activation markers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with T cell activation markers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and T cell activation markers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-779381