Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-07
1998-09-22
Walsh, Stephen
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 435 691, C07K 14705
Patent
active
058115188
ABSTRACT:
The invention provides substantially purified T-cadherin polypeptides and isolated nucleic acids which encode the T-cadherin polypeptides. Antibodies reactive with various forms of T-cadherin, but not reactive with N-, E- or P-cadherin are also provided. The invention provides methods for detecting the various forms of T-cadherin in a subject as well as a method of detecting tumor growth which consists of inhibiting the activity of T-cadherin in a tumor. A method of affecting traumatized neurons is provided. The method entails treating traumatized neurons with a therapeutically effective dose of T-cadherin.
REFERENCES:
patent: 5585351 (1996-12-01), Ranscht
Sigma Catalog, 1989, p. 116.
Neugehauer, et al., Chem. Abst. 109:167903c (1988).
Laemmli "Cleavage of Structural Proteins During the Assembly of the Head Bacteriophage T4." Nature 227:680-685 (1970).
Ranscht et al., "A Neuronal Surface Glycoprotein Associated with the Cytoskeleton." J. Cell Biol. 99:1803-1813 (1984).
Edelman et al., "Cellular Expression of Liver and Neural Cell Adhesion Molecules After Transfection with Their cDNAs Results in Specific Cell-Binding." Proc. Natl.Acad.Sci. USA 84:8502-8506 (1987).
Gallin et al., "Sequence Analysis of a cDNA Clone Encoding the Liver Cell Adhesion Molecule, L-CAM." Proc. Natl. Acad. Sci. USA 84:2808-2812 (1987).
Hatta et al., "Spatial and Temporal Expression Pattern of N-Cadherin Cell Adhesion Molecules Correlated with Morphogenetic Processes of Chicken Embryos." Dev. Biol. 120:215-217 (1987).
Nagafuchi et al.,"Transformation of Cell Adhesion Properties by Exogenously Introduced E-Cadherin cDNA." Nature 329:341-343 (1987).
Nose et al., "Isolation of Placental Cadherin cDNA: Identification of a Novel Gene Family of Cell-Adhesion Molecules." EMBO J. 6(12):3655-3661 (1987).
Ringwald et al., "The Structure of Cell Adhesion Molecule Uvomorulin. Insights into the Molecular Mechanism of Ca.sup.2 -dependent Cell Adhesion." EMBO J. 6(12):3647 (1987).
Hatta et al., "Cloning and Expression of cDNA Encoding a Neural Calcium-dependent Cell Adhesion Molecule: Its Identity in the Cadherin Gene Family." J. Cell. Biol. 106:873-881 (1988).
Mege et al., "Construction of Epithelioid Sheets by Transfection of Mouse Sarcoma Cells with cDNAs for Chicken Cell Adhesion Molecules." Proc. Natl. Acad. Sci. USA 85:7274-7278 (1988).
Nagafuchi and Takeichi, "Cell Binding Function of E-Cadherin is Regulated by the Cytoplasmic Domain." EMBO J. 7(12)3679-3684 (1988).
Neugebauer et al., "N-cadherin, NCAM, and Integrins Promote Retinal Neurite Outgrowth on Astrocytes in Vitro." Chem. Abstract 109:487 Abstract No. 109:167903c (1988).
Takeichi, "The Cadherins: Cell-Cell Adhesion Molecules Controlling Animal Morphogenesis." Development 102:639-655 (1988).
Kemler, and Ozawa, "Uvomorulin-Catenin Complex: Cytoplasmic Anchorage of a Ca.sup.2+ -dependent Cell Adhesion Molecule." BioEssays 11(4):88-91 (1989).
Moss and White, "A Ca.sup.2+ -sensitive Glycoprotein, GP90, Associated with the Cytoskeleton from Brain and Gizzard." J. Cell Sci. 93:85-94 (1989).
Nagafuchi and Takeichi, "Transmembrane Control of Cadherin-Mediated Cell Adhesion: a 94 kDa Protein Functionally Associated with a Specific Region of the Cytoplasmic Domain of E-Cadherin." Cell Regulation 1:37-44 (1989).
Ozawa et al., "The Cytoplasmic Domain of the Cell Adhesion Molecule Uvomorulin Associates with Three Independent Proteins Structurally Related in Different Species." EMBO J. 8(6):1711-1717 (1989).
Ranscht and Dours, "Selective Expression of a Novel Cadherin in the Pathways of Developing Motor and Commissural Axons." Society for Neuroscience Abstracts 15(part 1), Abstract No. 382.6 (1989).
Bixby and Zhang, "Purified N-Cadherin is a Potent Substrate for the Rapid Induction of Neurite Outgrowth." J. Cell Biol. 110:1253-1260 (1990).
Matsuzaki et al., "DNAs of Cell Adhesion Molecule of Different Specificity Induce Changes in Cell Shape and Border Formation in Cultured S180 Cells." J. Cell. Biol 110:1239-1252 (1990).
McNeill et al., "Novel Function of the Cell Adhesion Molecule Uvomorulin as an Inducer of Cell Surface Polarity." Cell 62:309-316 (1990).
Nose et al., "Localization of Specificity Determining Sites in Cadherin Cell Adhesion Molecules." Cell 61:147-155 (1990).
Ozawa et al., "Uvomorulin-catenin Complex Formation is Regulated by a Specific Domain in the Cytoplasmic Region of the Cell Adhesion Molecule." Proc. Natl. Acad. Sci. USA 87:4246-4250 (1990).
Ozawa and Kemler, "Correct Proteolytic Cleavage is required for the Cell Adhesive Function of Uvomorulin," J. Cell Biol. 111:1645-1650 (1990).
Ozawa et al., "Single Amino Acid Substitutions in one Ca.sup.2+ Binding Site of Uvomorulin Abolish the Adhesion Function." Cell 63:1033-1038 (1990).
Takeichi, "Cadherins: a Molecular Family Important in Selective Cell-Cell Adhesion." Annu. Rev. Biochem. 59:237-252 (1990).
Ranscht, "Cadherin Cell Adhesion Molecules in Vertebrate Neural Development." Seminars in the Neurosciences. 3:285-296 (1991).
Ranscht and Dours-Zimmerman, "T-Cadherin, A Novel Cadherin Cell Adhesion Molecule in the Nervous System Lacks the Conserved Cytoplasmic Region." Neuron 7:391-402 (1991).
Brown Karen E.
La Jolla Cancer Research Foundation
Walsh Stephen
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