T-Butyloxy-carbonyl-D-phenylalanyl-L-prolyl-L-arginine aldehyde

Details T-Butyloxy-carbonyl-D-phenylalanyl-L-prolyl-L-arginine aldehyde T-Butyloxy-carbonyl-D-phenylalanyl-L-prolyl-L-arginine aldehyde

1983-04-14

1984-10-23

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

044787456

ABSTRACT:
The invention relates to t-butyloxy-carbonyl-D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate and D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, which is highly stable in aqueous solution, and to a process for preparing D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or N.sup.G -carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the N.sup.G -carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anti-coagulant activity.

REFERENCES:
patent: 3826793 (1981-07-01), Blomback et al.
patent: 4316889 (1982-02-01), Bajusz et al.
patent: 4399065 (1983-08-01), Basjusz et al.

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