T-butyl (R)-(-)-4-cyano-3-hydroxybutyrate and process for prepar

Details T-butyl (R)-(-)-4-cyano-3-hydroxybutyrate and process for prepar T-butyl (R)-(-)-4-cyano-3-hydroxybutyrate and process for prepar

1994-07-11

1995-07-04

Brust, Joseph P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558342, C07C25512

Patent

active

054301718

ABSTRACT:
T-butyl (R)-(-)-4-cyano-3-hydroxybutyrate having an optical purity of 99%ee or higher and a process for producing the same are disclosed, the process comprising cyanogenation of a t-butyl (S)-(-)-4-halogeno-3-hydroxybutyrate obtained by enantioselective hydrogenation of a t-butyl 4-halogenoacetoacetate. Recrystallization of the resulting crude product gives the optically active compound with high optical purity.

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