Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-02-21
2010-06-29
Juedes, Amy E (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07745581
ABSTRACT:
Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.
REFERENCES:
patent: 5844082 (1998-12-01), Kishimoto et al.
patent: 6031078 (2000-02-01), Khodadoust
patent: 6037148 (2000-03-01), Khodadoust
patent: 6207414 (2001-03-01), Moore
patent: 7365169 (2008-04-01), Glimcher et al.
patent: 2003/0104528 (2003-06-01), Glimcher et al.
patent: 2003/0186377 (2003-10-01), Glimcher et al.
patent: 2005/0186568 (2005-08-01), Bandman et al.
patent: 2006/0084118 (2006-04-01), Glimcher et al.
patent: 2006/0223116 (2006-10-01), Glimcher et al.
patent: WO-99/11783 (1999-03-01), None
patent: WO-00/73453 (2000-12-01), None
patent: WO-03/048379 (2003-06-01), None
Owaki et al., 2006, J. Immunol. vol. 177: 7579-7587.
Li et al., 2003, Br. J. Opthalmol. vol. 87: 1264-67.
Alcaide, Pilar et al., “Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue,”The Journal of Experimental Medicine, vol. 204(2):431-439 (2007).
Ali, Majid et al., “Tyrosylprotein sulfotransferase-1 (TPST-1) does not regulate P-selectin-dependent rolling in vivo,” The FASEB Journal, vol. 17(5):A796, Abstract No. 512.2 (2003).
Aliprantis, Antonios O. et al., “Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13,”PNAS, vol. 104(8):2827-2830 (2007).
Arakawa, S. et al., “Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signaling in peripheral blood mononuclear cells of patients with atopic dermatitis,”Clin. Exp. Immunol., vol. 135:505-510 (2004).
Avni, Orly et al., “THcell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes,”Nature Immunology, vol. 3:643-651 (2002).
Bettelli, Estelle et al., “Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis,”J. Exp. Med., vol. 200(1):79-87 (2004).
Bulfone, Alessandro et al., “T-Brain-1: A Homolog ofBrachyuryWhose Expression Defines Molecularly Distinct Domains within the Cerebral Cortex,”Neuron, vol. 15:63-78 (1995).
Buono, Chiara et al., “T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses,”PNAS, vol. 102(5):1596-1601 (2005).
Chen, Chang-Hung et al., “Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation,”J. Exp. Med., vol. 197(12):1689-1699 (2003).
Dorfman, David M. et al., “Differential Expression of T-bet, a T-box Transcription Factor Required for Th1 T-Cell Development, in Peripheral T-Cell Lymphomas,”Am. J. Clin. Pathol., vol. 120(6):866-873 (2003).
Dorfman, David M. et al., “T-bet, a T-Cell-Associated Transcription Factor is Expressed in a Subset of B-Cell Lymphoproliferative Disorders,”Am. J. Clin. Pathol., vol. 122:292-297 (2004).
Dorfman, David M. et al., “T-bet, a T-Cell-Associated Transcription Factor is Expressed in Hodgkin's lymphoma,”Human Pathology, vol. 36:10-15 (2005).
Ehrhardt, Carsten et al., “Selectins—an emerging target for drug delivery,”Advanced Drug Delivery Reviews, vol. 56:527-549 (2004).
EMBL Accession No. AF093098, Zhang, W.X. et al., “Cloning and Characterization of a New Member of the T-Box Gene Family,”Genomics, vol. 70(1):41-48 (2000).
Fargeas, Christine et al., “Differential effect of transforming growth factor β on the synthesis of Th1- and Th2-like lymphokines by human T lymphocytes,”Eur. J. Immunol., vol. 22:2173-2176 (1992).
Finotto, Susetta et al., “Asthmatic changes in mice lacking T-bet are mediated by IL-13,”International Immunology, vol. 17(8):993-1007 (2005).
Finotto, Susetta et al., “Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet,”Science, vol. 295:336-338 (2002).
Garrett, Wendy S. et al., “Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System,”Cell, vol. 131:33-45 (2007).
Geng, Jian-Guo et al., “P-selectin Cell Adhesion Molecule in Inflammation, Thrombosis, Cancer Growth and Metastasis,”Current Medicinal Chemistry, vol. 11:2153-2160 (2004).
Gerth, Andrea J. et al., “An Innate Cell-Mediated, Murine Ulcerative Colitis-like Syndrome in the Absence of Nuclear Factor of Activated T Cells,”Gastroenterology, vol. 126:1115-1121 (2004).
Glimcher, Laurie H. et al., “Recent Developments in the Transcriptional Regulation of Cytolytic Effector Cells,”Nature, vol. 4:900-911 (2004).
Glimcher, Laurie H. et al., “Transcription Factors in Lymphocyte Development—T and B Cells Get Together,”Cell, vol. 96:13-23 (1999).
Glimcher,,Laurie H., “Trawling for treasure: tales of T-bet,”Nature Immunology, vol. 8(5):448-450 (2007) .
Harlow, Ed et al., Antibodies, A Laboratory Manual, Cold Spring Harbor Laboratory, pp. vi, 321-322 (1988).
Ho, I-Cheng et al., “Transcription: Tantalizing Times for T Cells,”Cell, vol. 109:S109-S120 (2002).
Hsieh, Chyi-Song et al., “Development of TH1 CD4+T Cells Through IL-12 Produced byListeria-Induced Macrophages,”Science, vol. 260:547-549 (1993).
Hwang, Eun Sook et al., “IL-2 production in developing Th1 cells is regulated by heterodimerization of Re1A and T-bet and requires T-bet serine residue 508,”JEM, vol. 202(9):1289-1300 (2005).
Hwang, Eun Sook et al., “T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3,”Science, vol. 307:430-433 (2005).
Juedes, Amy E. et al., “T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes,”J. Exp. Med., vol. 199(8):1153-1162 (2004).
Kashiwakura, Jun-ichi et al., “Txk, a Nonreceptor Tyrosine Kinase of the Tec Family, Is Expressed in T Helper Type 1 Cells and Regulates Interferon γ Production in Human T Lymphocytes,”J. Exp. Med., vol. 190(8):1147-1154 (1999).
Lametschwandtner, Günther et al., “Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities,”J. Allergy Clin. Immunol., vol. 113:987-994 (2004).
Lord, Graham M. et al., “T-bet is required for optimal proinflammatory CD4+T-cell trafficking,”Blood, vol. 106(10):3432-3439 (2005).
Lugo-Villarino, Geanncarlo et al., “T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells,”PNAS, vol. 100(13):7749-7754 (2003).
Lugo-Villarino, Geanncarlo et al., “The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells,”PNAS, vol. 102(37):13248-13253 (2005).
Lutters, Bianca C.H. et al., “Blocking endothelial adhesion molecules: a potential therapeutic strategy to combat atherogenesis,”Current Opinion in Lipidology, vol. 15:545-552 (2004).
Macatonia, Steven E. et al., “Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent,”International Immunology, vol. 5(9):1119-1128 (1993).
Maggi, Enrico et al., “R
Glimcher Laurie H.
Szabo Susanne J.
DeConti, Jr. Giulio A.
Juedes Amy E
Lahive & Cockfield LLP
President and Fellows of Harvard College
Williams Megan E.
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