Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-07-01
2008-07-01
Ewoldt, G. R. (Department: 1644)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C435S455000, C435S069100
Reexamination Certificate
active
07393944
ABSTRACT:
Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.
REFERENCES:
patent: 5844082 (1998-12-01), Kishimoto et al.
patent: 6031078 (2000-02-01), Khodadoust
patent: 2003/0186377 (2003-10-01), Glimcher et al.
patent: WO 99/11783 (1999-03-01), None
patent: WO 99/11783 (1999-03-01), None
patent: WO 00/73453 (2000-12-01), None
Webster's New World Dictionary (Neufeldt and Guralnik, Eds.), Third College Edition, Ney York, 1988, p. 1080.
Bulfone et al., 1995, Neuron, vol. 15: 63-78.
Bulfone, et al. “T-brain-1: a Homolog of Brachyury whose Expression Defines Molecularly Distinct Domains within a Cerebral Cortex.”Neuron15(1):63-78 (Jul. 1995).
EMBL Acession No. AF093098 forHomo sapienstranscription factor TBLYM (TBLYM) mRNA, complete cds. Dec. 7, 2000.
Mullen, et al. “Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection.”Science292:1907-1910 (Jun. 2001).
Smith “T-box Genes: What They Do and How They Do It.”Trends Genet. 15(4):154-158 (Apr. 1999).
Szabo, et al. “A Novel Transcription Factor, T-bet, Directs Th1Lineage Commitment.”Cell100:655-669 (Mar. 2000).
Zhang, et al. “Cloning and Characterization of a New Member of the T-Box Gene Family.”Genomics70(1):41-48 (2000).
Glimcher Laurie H.
Szabo Susanne J.
DeConti Giulio A.
Ewoldt G. R.
Juedes Amy
Lahive & Cockfield LLP
President and Fellows of Harvard College
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