T.alpha.1 .alpha.-tubulin promoter and expression vectors

Details T.alpha.1 .alpha.-tubulin promoter and expression vectors T.alpha.1 .alpha.-tubulin promoter and expression vectors

1994-03-18

1997-08-26

Crouch, Deborah

Chemistry: molecular biology and microbiology

Vector, per se

536 241, 935 33, 935 34, C12N 1500, C07H 2104

Patent

active

056610327

ABSTRACT:
The present invention relates to a DNA expression vector comprising a T.alpha.1 .alpha.-tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage and said promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention said material and detecting said expressed marker gene as an indication of neurogenesis and neuronal growth.

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