Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-04-06
2009-10-27
Kim, Young J (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
07608396
ABSTRACT:
Systems, tools and methods are used to perform complex sandwich hybridization assays of biological material. The tools comprise biological solution probes having a first region for hybridizing to capture probes on a universal assay apparatus, and a second region for hybridizing to a sample target. The solution probe assembles the target to the apparatus by hybridizing the second region to the target and the first region to the capture probe. Multiple biological samples, having a plurality of targets per sample, can be multiplexed on the same universal array. The customized solution probe addresses and assembles a predetermined target-sample combination onto the array at a corresponding capture probe address location. Specificity and sensitivity of the assay are provided by the incorporation of a modified monomer in the capture probe and a similarly modified monomer complement in the first region of the solution probe. The modified monomers preferentially hybridize with each other.
REFERENCES:
patent: 4716106 (1987-12-01), Chiswell
patent: 4731325 (1988-03-01), Palva et al.
patent: 4751177 (1988-06-01), Stabinsky
patent: 4868105 (1989-09-01), Urdea et al.
patent: 4894325 (1990-01-01), Englehardt et al.
patent: 5194599 (1993-03-01), Froehler
patent: 5200314 (1993-04-01), Urdea
patent: 5399676 (1995-03-01), Froehler
patent: 5437976 (1995-08-01), Utermohlen
patent: 5527899 (1996-06-01), Froehler
patent: 5556749 (1996-09-01), Mitsuhashi et al.
patent: 5604097 (1997-02-01), Brenner
patent: 5635352 (1997-06-01), Urdea et al.
patent: 5635400 (1997-06-01), Brenner
patent: 5663318 (1997-09-01), Pegg et al.
patent: 5681697 (1997-10-01), Urdea et al.
patent: 5681702 (1997-10-01), Collins et al.
patent: 5721218 (1998-02-01), Froehler
patent: 5780610 (1998-07-01), Collins et al.
patent: 5800992 (1998-09-01), Fodor et al.
patent: 5846719 (1998-12-01), Brenner et al.
patent: 5858671 (1999-01-01), Jones
patent: 5871902 (1999-02-01), Weininger et al.
patent: 5922617 (1999-07-01), Wang et al.
patent: 6083763 (2000-07-01), Balch
patent: 6110678 (2000-08-01), Weisburg et al.
patent: 6185561 (2001-02-01), Balaban et al.
patent: 6232066 (2001-05-01), Felder et al.
patent: 7052841 (2006-05-01), Delenstarr
patent: 0 799 897 (1997-10-01), None
patent: WO 96/41011 (1996-12-01), None
patent: WO 97/31256 (1997-08-01), None
Daniel D. Shoemaker, et al., “Quantitative Phenotypic Analysis of Yeast Deletion Mutants Using A Highly Parallel Molecular Bar-Coding Strategy”,Nature Genetics, vol. 14, pp. 450-456, Dec. 1996.
M. Koga, et al., “Alternating α, β- Oligothymidylates with Alternating (3′→3′)- and (5′→5′)- Internucleotidic Phosphodiester Linkages as Models for Antisense Oligodeoxyribonucleotides”,The Journal of Organic Chemistry, vol. 56, No. 12, Jun. 7, 1991, pp. 3757-3759.
M. Koga, et al., “The synthesis of alternating α, β- oligodeoxyribonucleotides with alternating (3′→3′)- and (5′→5′)-internucleotic linkages as potential therapeutic agents”,Nucleic Acids Symposium Series, No. 29, pp. 3-4 (1993).
M. Koga, et al., “Synthesis and Physicochemical Properties of Alternating (3′→3′)- and (5′→5′)- Internucleotidic Phosphodiester Linkages”,J. Org. Chem. 1995, 60, 1520-1530.
Agilent Technologies
Kim Young J
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