Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2011-05-03
2011-05-03
Lin, Jerry (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
Reexamination Certificate
active
07937225
ABSTRACT:
The present invention relates to systems, methods and software arrangements for the detection of variations in the copy number of a gene in a genome. These systems, methods and software arrangements are based on a simple prior model that uses a first process generating amplifications and deletions in the genome, and a second process modifying the signal obtained to account for the corrupting noise inherent in the technical methodology used to scan the genome. A Bayesian approach according to the present invention determines, e.g., the most plausible hypothesis of regional changes in the genome and their associated copy number. The systems, methods, and software arrangements can be are framed as optimization problems, in which a score function is minimized. The system, methods and software arrangements may be useful to assist the scientific study, diagnosis and/or treatment of any disease which has a genetic component, including but not limited to cancers and inherited diseases.
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Daruwala Raoul-Sam
Mishra Bhubaneswar
Rudra Archisman
Dorsey & Whitney LLP
Lin Jerry
New York University
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