Systems, methods, and compositions for achieving closure of...

Details Systems, methods, and compositions for achieving closure of... Systems, methods, and compositions for achieving closure of...

2004-10-22

2008-01-15

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S486000, C514S021800, C606S214000

Reexamination Certificate

active

07318933

ABSTRACT:
Systems, methods, and compositions achieve rapid closure of vascular puncture sites. The systems and methods form a vascular closure composition by mixing together a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material having a functionality of at least three. The second component includes a nucleophilic material that, when mixed with the first component within a reaction pH range of between 7 to 9, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material has a pH within the reaction pH range. The systems and methods apply the composition to seal a vascular puncture site.

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