Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-08-08
2006-08-08
Graser, Jennifer E. (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C536S023700, C536S024100, C536S024200, C435S320100, C435S069100, C435S243000, C435S252300, C530S350000, C424S234100, C424S192100, C424S193100
Reexamination Certificate
active
07087410
ABSTRACT:
The present invention relates to an expression system for the expression of proteins and peptides in a methanotrophic bacterium, preferable theM. capsulatus. Further, the invention relates to the exportation and display of said peptides and proteins on the surface of said bacteria. The invention also describes a method for the production of a desired protein in theM. capsulatus.
REFERENCES:
Zhuang et al., “CaulobacterFliQ and FliR Membrane Proteins, Required for Flagellar Biogenesis and Cell Division, Belong to a Family of Virulence Factor Export Proteins,” Journal of Bacteriology 1995; 177: 343-356.
Loosmore et al., “Outer Membrane Protein D15 Is Conserved amongHaemophilus influenzaeSpecies and May Represent a Universal Protective Antigen against Invasive Disease,” Infection and Immunity 1997; 65(9): 3701-3707.
Georgiou et al., “Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines,” Nature Biotechnology 1997; 15: 29-34.
Fjellbirkeland et al., “Outer membrane proteins ofMethylococcus capsulatus(Bath),” Arch Microbiol 1997; 168: 128-135.
Fjellbirkeland et al., “Molecular analysis of an outer membrane protein, MopB, ofMethylcoccus capsulatus(Bath) and structural comparisons with proteins of the OmpA family,” Arch Microbiol 2000; 173: 346-351.
Fjellbirkeland et al., “The C-terminal part of the surface-associated protein MopE of the methanotrophMethylcoccus capsulatus(Bath) is secreted into the growth medium,” Arch Microbiol 2001; 176: 197-203, Sep. 2001.
International Search Report for PCT Application No. PCT/NO02/00018 issued by the Swedish Patent Office on Jun. 25, 2002.
Birkeland Nils Kåre
Durkin A. Scott
Eidhammer Ingvar
Eisen Jonathan A.
Fraser Claire M.
Graser Jennifer E.
Reed Smith LLP
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