Liquid purification or separation – Processes – Chromatography
Patent
1999-05-25
2000-10-24
Therkorn, Ernest G.
Liquid purification or separation
Processes
Chromatography
210659, 2101982, 95 82, B01D 1508
Patent
active
061361976
ABSTRACT:
The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.
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Brockman Fred J.
Bruckner-Lea Cynthia J.
Chandler Darrell P.
Egorov Oleg B.
Grate Jay W.
Battelle (Memorial Institute)
Therkorn Ernest G.
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