Systems and methods for topical treatment with nitric oxide

Details Systems and methods for topical treatment with nitric oxide Systems and methods for topical treatment with nitric oxide

2006-05-23

2006-05-23

Reamer, James H (Department: 1614)

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Nitrates or nitrites or nitric acid or nitrogen oxides

C514S474000, C514S458000, C514S578000

Reexamination Certificate

active

07048951

ABSTRACT:
A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline™) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.

REFERENCES:
patent: 6103275 (2000-08-01), Seitz et al.
Tucker et al, Lancet, vol. 354, #9191, pp. 1670-75 (Nov. 1999).

Affiliated with

Also associated with

Rating

Systems and methods for topical treatment with nitric oxide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Systems and methods for topical treatment with nitric oxide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systems and methods for topical treatment with nitric oxide will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3618289