Systems and methods for screening pharmaceutical chemicals

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of culturing cells in suspension

Reexamination Certificate

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C435S325000, C435S395000

Reexamination Certificate

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08071381

ABSTRACT:
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and hysteresis.

REFERENCES:
patent: 4593042 (1986-06-01), Liang
patent: 4705785 (1987-11-01), Schwedner et al.
patent: 4839280 (1989-06-01), Banes
patent: 4940853 (1990-07-01), Vandenburgh
patent: 4940856 (1990-07-01), Bock
patent: 5038795 (1991-08-01), Roush et al.
patent: 5326357 (1994-07-01), Kandel
patent: 5464853 (1995-11-01), Chan et al.
patent: 5571083 (1996-11-01), Lemelson
patent: 5665391 (1997-09-01), Lea
patent: 5706815 (1998-01-01), Sarvazyan et al.
patent: 6197575 (2001-03-01), Griffith et al.
patent: 6332364 (2001-12-01), Buschmann
patent: 7449306 (2008-11-01), Elson et al.
patent: 2003/0091979 (2003-05-01), Eschenhagen
patent: 2006/0105357 (2006-05-01), Benesch et al.
patent: 2008/0038812 (2008-02-01), Elson et al.
patent: 19500498 (1996-07-01), None
patent: 1250416 (2006-05-01), None
patent: WO 90/00595 (1990-01-01), None
patent: WO 01/55297 (2001-08-01), None
patent: 03/016860 (2003-02-01), None
United States Patent Office Action for U.S. Appl. No. 11/774,393 dated Dec. 4, 2009 (10 pages).
Canadian Patent Office Action for Application No. 2,497,343 dated Feb. 11, 2010 (3 pages).
Allen, F.D. et al., “Calpain regulated cell adhesion in EGF-stimulated fibroblast-populated-collagen-lattice contraction,” BED (American Society of Mechanical Engineers), 50 (Proceedings of the Bioengineering Conference, Jun. 27-Jul. 1, 2001), 353-354.
Dewolf, C. et al., “Interaction of dystrophin fragments with model membranes,” Biophys. J. (1997) 72:2599-2604.
Eschenhagen, T. et al., “Transfection studies using a new cardiac 3D gel system,” Molecular Approaches to Heart Failure Therapy, Hasenfuss et al. eds., Verlag Gmbh & Co., Germany (2000) 144-156.
Eschenhagen, T. et al., “Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system,” FASEB J. (1997) 11(8):683-694.
Fink, C. et al., “Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement,” FASEB J. (2000) 14(5):669-679.
Floyd Jr., S.S. et al., “Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles,” Gene Therapy (1998) 5:19-30.
Kolodney, M.S. et al., “Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts,” J. Biol. Chem. (1993) 268(32):23850-23855.
Kolodney, M.S. et al., “Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study,” J. Cell Biol. (1992) 117(1):73-82.
Pasternak, C. et al., “Mechanical function of dystrophin in muscle cells,” J. Cell Biol. (1995) 128(3):355-361.
Paul, R.J. et al., “Effects of microtubule disruption on force, velocity, stiffness and [Ca2+] in porcine coronary arteries,” Am. J. Physiol. Heart Circ. Physiol. (2000) 279:H2493-H2501.
Petersen, N.W. et al., “Dependence of locally measured cellular deformability on position on the cell, temperature, and cytochalasin B,” Proc. Natl. Acad. Sci. USA (1982) 79:5327-5331.
Shen, X. et al., “Pharmacological modulation of the mechanical response of airway smooth muscle to length oscillation,” J. Appl. Physiol. (1997) 83(3):739-745.
Sundberg, S.A., “High-throughput and ultra-high-throughput screening: solution- and cell-based approaches,” Curr. Opin. Biotechnol. (2000) 11:47-53.
Wakatsuki , T. et al., “Phenotypic screening for pharmaceuticals using tissue constructs,” Curr. Pharm. Biotech. (2004) 5(2):181-189.
Wakatsuki et al., “Cell mechanics studied by a reconsituted model tissue,” Biophys. J. (2000) 79:2353-2368.
Wakatsuki, T. et al, “Effects of cytochalasin D and latrunculin B on mechanical properties of cells,” J. Cell Science (2001) 114(5):1025-1036.
Website for Webster's Third International Dictionary, unabridged, www.lionreference.chadwyck.com, 6 pages; retrieved on Sep. 19, 2006.
Zahalak, G.I. et al., “Determination of cellular mechanical properties by cell poking, with an application to leukocytes,” J. Biomech. Engin. (1990) 112:283-294.
Zimmerman, W.H. et al., “Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes,” Biotech. Bioeng. (2000) 68(1):106-114.
United States Office Action for U.S. Appl. No. 10/219,097 dated Dec. 14, 2005 (13 pages).
United States Office Action for U.S. Appl. No. 10/219,097 dated Sep. 29, 2006 (9 pages).
United States Office Action for U.S. Appl. No. 10/219,097 dated Oct. 9, 2007 (8 pages).
United States Office Action for U.S. Appl. No. 10/219,097 dated Apr. 8, 2008 (5 pages).
International Search Report for PCT/US02/25761 dated Apr. 21, 2003 (5 pages).
Written Opinion for PCT/US02/25761 dated Aug. 5, 2004 (6 pages).
International Preliminary Report on Patentability for PCT/US02/25761 dated Feb. 17, 2005 (6 pages).
Takakuda, K. et al., “Strengthening of fibrous tissues under mechanical stimuli (in vitro experiments),” JSME Int. J. Ser. A. (1998) 41:576-583.
European Patent Office Search Report for Application No. 02752832.2 dated Feb. 22, 2005 (3 pages).
European Patent Office Action for Application No. 02752832.2 dated Sep. 16, 2005 (4 pages).
European Patent Office Action for Application No. 02752832.2 dated Apr. 4, 2007 (4 pages).
European Patent Office Action for Application No. 02752832.2 dated Mar. 10, 2008 (4 pages).
European Patent Office Action for Application No. 02752832.2 dated Jul. 24, 2008 (5 pages).
European Patent Office Action for Application No. 08009189.5 dated Sep. 22, 2008 (8 pages).
European Patent Office Action for Application No. 08009189.5 dated Mar. 23, 2010 (4 pages).
Japanese Patent Office Action for Application No. 2003-521318 dated Mar. 17, 2009 (10 pages) with English translation.
Japanese Patent Office Action for Application No. 2003-521318 dated Jun. 10, 2008 (5 pages) with English translation.
Japanese Patent Office Action for Application No. 2003-521318 dated Apr. 6, 2010 (4 pages) English translation only.
United States Patent Office Action for U.S. Appl. No. 11/774,393 dated Aug. 24, 2010 (13 pages).
European Patent Office Action for Application No. 08009189.5 dated Oct. 13, 2010 (4 pages).
United States Patent Office Action for U.S. Appl. No. 11/774,393 dated Jan. 31, 2011 (17 pages).
United States Patent Office Action for U.S. Appl. No. 11/774,393 dated Apr. 12, 2011 (17 pages).

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