Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving fixed or stabilized – nonliving microorganism,...
Reexamination Certificate
2002-08-14
2008-11-11
Marx, Irene (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving fixed or stabilized, nonliving microorganism,...
C435S040500, C435S325000, C435S371000
Reexamination Certificate
active
07449306
ABSTRACT:
A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and hysteresis.
REFERENCES:
patent: 4593042 (1986-06-01), Liang
patent: 4705785 (1987-11-01), Schwedner et al.
patent: 5038795 (1991-08-01), Roush et al.
patent: 5326357 (1994-07-01), Kandel
patent: 5464853 (1995-11-01), Chan et al.
patent: 5571083 (1996-11-01), Lemelson
patent: 5665391 (1997-09-01), Lea
patent: 5706815 (1998-01-01), Sarvazyan et al.
patent: 6332364 (2001-12-01), Buschmann et al.
patent: 2003/0091979 (2003-05-01), Eschenhagen
patent: 2006/0105357 (2006-05-01), Benesch et al.
patent: 19500498 (1996-07-01), None
patent: 1 250 416 (2006-05-01), None
patent: 2001/00856 (2001-08-01), None
patent: WO 03/016860 (2003-02-01), None
Paul et al. Effects of microtubules disruption on force, velocity, stiffness and [Ca2+}i in procine coronary arteries. Am. J. Physiol. Heart Circ. Physiol. (Nov. 2000) 279: H24-H2501.
Wakatsuki et al. Cell Machanics studies by a reconstituted model tissue, Biophysical J. (Nov. 2000) 79: 2353-2368.
Shen et al. Pharmacological modulation of the mechanical response of airway smooth muscle to length oscillation. J. Appl. Physiol. (1997) 83(3): 739-745.
Kolodney et al. Isometric contration by fibroblasts and endothelial cells in tissue culture: A quantitative study. J. Cell Biol. (1992) 117(1): 73-82.
Floyd et al. Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles. Gene Therapy (1997) 5: 19-30.
Pasternak et al. Mechanical function of dystrophin in muscle cells. J. Cell Biol. (1995) 128(3): 355-361.
DeWolf et al. Interaction of dystrophin fragments with model membranes. Biophys. J. (1997) 72(6): 2599-2604.
Web site for Webster's Third International Dictionary, unabridged, www.lionreference.chadwyck.com, 6 pages; retrieved on Sep. 19, 2006.
Allen, F.D. et al., “Calpain regulated cell adhesion in EGF-stimulated fibroblast-populated-collagen-lattice contraction,” BED (American Society of Mechanical Engineers), 50 (Proceedings of the Bioengineering Conference, Jun. 27-Jul. 1, 2001), 353-354.
Eschenhagen, T. et al., “ Transfection studies using a new cardiac 3D gel system,” Molecular Approaches to Heart Failure Therapy, Hasenfuss et al. eds., Verlag Gmbh & Co., Germany (2000) 144-156.
Eschenhagen, T. et al., “Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system,” FASEB J. (1997) 11(8):683-694.
Fink, C. et al., “Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement,” FASEB J. (2000) 14(5):669-679.
Kolodney, M.S. et al., “Correlation of myosin light chain phosphorylation with isometric contraction of fibroblasts,” J. Biol. Chem. (1993) 268(32):23850-23855.
Petersen, N.W. et al., “Dependence of locally measured cellular derformability on position on the cell, temperature, and cytochalasin B,” Proc. Natl. Acad. Sci. USA (1982) 79:5327-5331.
Sundberg, S.A., “High-throughput and ultra-high-throughput screening: solution- and cell-based approaches,” Curr. Opin. Biotechnol. (2000) 11:47-53.
Wakatsuki, T. et al., “Phenotypic screening for pharmaceuticals using tissue constructs,” Curr. Pharm. Biotech. (2004) 5(2):181-189.
Wakatsuki, T. et al, “Effects of cytochalasin D and latrunculin B on mechanical properties of cells,” J. Cell Science (2001) 114(5):1025-1036.
Zahalak, G.I. et al., “Determination of cellular mechanical properties by cell poking, with an application to leukocytes,” J. Biomech. Engin. (1990) 112:283-294.
Zimmerman, W.H. et al., “Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes,” Biotech. Bioeng. (2000) 68(1):106-114.
Elson Elliot
McConnaughey William B.
Wakatsuki Tetsuro
Hanley Susan
Marx Irene
Michael & Best & Friedrich LLP
Washington University in St. Louis
LandOfFree
Systems and methods for screening pharmaceutical chemicals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Systems and methods for screening pharmaceutical chemicals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Systems and methods for screening pharmaceutical chemicals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4039047