Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition
Patent
1997-01-23
2000-02-15
McKane, Elizabeth
Chemical apparatus and process disinfecting, deodorizing, preser
Control element responsive to a sensed operating condition
422 65, 422 99, 222394, 7386415, 7386422, 7386424, 7386425, B01L 300, B01L 302
Patent
active
060249250
ABSTRACT:
The invention provides, in one aspect, serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. In one embodiment, the invention provides a tool that allows the parallel development of a sample array. To this end, the tool can be understood as an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding manual liter volumes of fluid. Each of the pins can fit inside a housing that forms an interior chamber. The interior chamber can be connected to a pressure source that will control the pressure within the interior chamber to regulate the flow of fluid within the interior chamber of the pins. In a further embodiment, the invention then passes the prepared sample arrays to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.
REFERENCES:
patent: 3568735 (1971-03-01), Lancaster
patent: 3807235 (1974-04-01), Lefkovitz et al.
patent: 3999689 (1976-12-01), Ciantro
patent: 4461328 (1984-07-01), Kenney
patent: 4548245 (1985-10-01), Crandell et al.
patent: 4779467 (1988-10-01), Rainin et al.
patent: 4844298 (1989-07-01), Ohoka et al.
patent: 4931400 (1990-06-01), Jitsukawa
patent: 5000921 (1991-03-01), Hanaway et al.
patent: 5077210 (1991-12-01), Eigler et al.
patent: 5108703 (1992-04-01), Pfost et al.
patent: 5195657 (1993-03-01), Wells
patent: 5869242 (1999-02-01), Kamb
Arshady, Reza, Beaded polymer supports and gels: I. Manufacturing techniques, Journal of Chromatography, 586:181-197 (1991).
Arshady, Reza, Beaded polymer supports and gels: II. Physico-chemical criteria and functionalization, Journal of Chromatography, 586:199-219 (1991).
Batista-Viera et al., A new method for reversible immobilization of thiol biomolecules bsed on solid-phase bound thiolsulfonate groups, App. Biochem and Biotech,31:175-195 (1991).
English version of Japanese Patent, JP63230086 A 880926 DW8844, WPI/Derwent, AN88-311964, Carry immobilise physiological active substance comprise bind chain form di sulphide compound epoxy group latex contain polymer particle. Sep. 26, 1988.
English version of Japanese Patent, JP2215399 A 90028 DW9040, WPI/Derwent, AN90-302767, Method detect DNA de single strand combination DNA prime correspond base sequence forming replica. Aug. 28, 1990.
Hayashi et al., Immobilization of thiol proteases onto porous poly(vinyl alcohol) beads, Polymer Journal, 25:5, 489-497 (1993).
Manoharan et al., A 2'-O-thiol tether in the ribose moiety of nucleic acids for conjugation chemistry, Gene, 149:147-156 (1994).
Pon, et al., Derivation of controlled pore glass beads fo rsolid phase oligonucleotide synthesis, BioTechniques, 6:8, 770-775 (1988).
Zukermann et al., Efficient methods for attachment of thiol specific probes to the 3'-ends of synthetic oligodeoxyribonucleotides, Nucleic Acids Research, 15:13, 5305-5321 (1987).
Kozal et al., "Extensive Polymorphisms Observed in HIV-1 Clade B Protease Gene Using High-Density Oligonucleotide Arrays", Nature Medicine, vol. 2, No. 7, pp. 753-759, (Jul. 1996).
Wallace, "Ink-Jet Based Fluid Microdispensing in Biochemical Applications", Microfab Technologies, Inc., Laboratory Automation News, vol. 1, No. 5, pp. 6-9, (Nov. 1996).
Koster Hubert
Little Daniel P.
McKane Elizabeth
Moazzam Fariborz
Seidman Stephanie L.
Sequenom Inc.
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