Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...
Reexamination Certificate
2007-06-19
2007-06-19
Gakh, Yelena G. (Department: 1743)
Chemistry: analytical and immunological testing
Nuclear magnetic resonance, electron spin resonance or other...
C436S180000, C250S287000, C250S425000
Reexamination Certificate
active
09364774
ABSTRACT:
Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The resulting substrates are also provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array. The prepared sample arrays are passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry. To this end, a mass spectrometer is provided that generates a set of spectra signals that are indicative of the composition of the sample material under analysis.
REFERENCES:
patent: 3776700 (1973-12-01), Gallant
patent: 4740692 (1988-04-01), Yamamoto et al.
patent: 4952518 (1990-08-01), Johnson et al.
patent: 5175209 (1992-12-01), Beattie et al.
patent: 5288644 (1994-02-01), Beavis et al.
patent: 5350676 (1994-09-01), Oberhardt et al.
patent: 5399501 (1995-03-01), Pope et al.
patent: 5498545 (1996-03-01), Vestal
patent: 5506348 (1996-04-01), Pieles
patent: 5512295 (1996-04-01), Kornberg et al.
patent: 5514548 (1996-05-01), Krebber et al.
patent: 5547835 (1996-08-01), Koster
patent: 5580434 (1996-12-01), Robotti et al.
patent: 5609907 (1997-03-01), Natan
patent: 5643800 (1997-07-01), Tarantino et al.
patent: 5663242 (1997-09-01), Ghosh et al.
patent: 5700642 (1997-12-01), Monforte et al.
patent: 5716825 (1998-02-01), Hancock et al.
patent: 5742049 (1998-04-01), Holle et al.
patent: 5743960 (1998-04-01), Tisone
patent: 5770272 (1998-06-01), Biemann
patent: 5770860 (1998-06-01), Franzen
patent: 5777324 (1998-07-01), Hillenkamp
patent: 5812272 (1998-09-01), King et al.
patent: 5828063 (1998-10-01), Koster et al.
patent: 5854486 (1998-12-01), Dreyfus
patent: 5864137 (1999-01-01), Becker et al.
patent: 5872010 (1999-02-01), Karger et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5925520 (1999-07-01), Tully et al.
patent: 5927547 (1999-07-01), Papen et al.
patent: 5965363 (1999-10-01), Monforte et al.
patent: 5969350 (1999-10-01), Kerley et al.
patent: 5981185 (1999-11-01), Matson et al.
patent: 5985356 (1999-11-01), Schultz et al.
patent: 6024925 (2000-02-01), Little et al.
patent: 6040193 (2000-03-01), Winkler et al.
patent: 6051378 (2000-04-01), Monforte et al.
patent: 6079283 (2000-06-01), Papen et al.
patent: 6083762 (2000-07-01), Papen et al.
patent: 6090558 (2000-07-01), Butler et al.
patent: 6104028 (2000-08-01), Hunter et al.
patent: 6110426 (2000-08-01), Shalon et al.
patent: 6121048 (2000-09-01), Zaffaroni et al.
patent: 6136269 (2000-10-01), Winkler et al.
patent: 6194144 (2001-02-01), Köster
patent: 6197498 (2001-03-01), Köster
patent: 6207370 (2001-03-01), Little et al.
patent: 6221601 (2001-04-01), Köster et al.
patent: 6221605 (2001-04-01), Köster
patent: 6225061 (2001-05-01), Becker et al.
patent: 6225450 (2001-05-01), Köster
patent: 6235478 (2001-05-01), Köster
patent: 6238871 (2001-05-01), Köster
patent: 6258538 (2001-07-01), Köster et al.
patent: 6265716 (2001-07-01), Hunter et al.
patent: 6268131 (2001-07-01), Kang et al.
patent: 6268144 (2001-07-01), Köster
patent: 6277573 (2001-08-01), Koster
patent: 6287872 (2001-09-01), Schurenberg et al.
patent: 6300076 (2001-10-01), Köster
patent: 6303309 (2001-10-01), Jurinke et al.
patent: 6322970 (2001-11-01), Little et al.
patent: 6342396 (2002-01-01), Perrin et al.
patent: 6376044 (2002-04-01), Jarrell et al.
patent: 6387628 (2002-05-01), Little et al.
patent: 6428955 (2002-08-01), Köster et al.
patent: 6485913 (2002-11-01), Becker et al.
patent: 6500621 (2002-12-01), Köster
patent: 6558902 (2003-05-01), Hillenkamp
patent: 6566055 (2003-05-01), Monforte et al.
patent: 6569385 (2003-05-01), Little et al.
patent: 6589485 (2003-07-01), Köster
patent: 6602662 (2003-08-01), Köster et al.
patent: 6635452 (2003-10-01), Monforte et al.
patent: 6670609 (2003-12-01), Franzen et al.
patent: 2002/0109085 (2002-08-01), Hillenkamp et al.
patent: 2003/0022225 (2003-01-01), Monforte et al.
patent: 2003/0113745 (2003-06-01), Monforte et al.
patent: 2003/0228594 (2003-12-01), Koster et al
patent: WO-9803257 (1998-01-01), None
patent: 19731479 (1998-08-01), None
patent: 0396116 (1990-11-01), None
patent: 0543550 (1993-05-01), None
patent: 1262564 (1994-01-01), None
patent: 1271609 (1997-09-01), None
patent: 1164203 (1997-11-01), None
patent: 2233654 (1991-01-01), None
patent: 2312782 (1997-11-01), None
patent: 2332273 (1999-06-01), None
patent: 2215399 (1990-08-01), None
patent: A-8-233710 (1996-09-01), None
patent: 8805074 (1988-07-01), None
patent: 8912624 (1989-12-01), None
patent: 9314108 (1993-07-01), None
patent: 9403774 (1994-02-01), None
patent: 9427719 (1994-12-01), None
patent: 9511755 (1995-05-01), None
patent: 9525116 (1995-09-01), None
patent: 9525175 (1995-09-01), None
patent: 9535505 (1995-12-01), None
patent: 9619587 (1996-06-01), None
patent: 9803257 (1998-01-01), None
patent: 9805965 (1998-02-01), None
patent: 9822541 (1998-05-01), None
patent: 9834116 (1998-08-01), None
patent: 9839481 (1998-09-01), None
Li et al. “Analysis of Single Mammalian Cell Lysates by Mass Spectrometry”, J. Am. Chem. Soc., 1996, 118, pp. 11662-11663.
Beattie et al., “Synthesis and use of oligonucleotide libraries”,Chem. Abst., 123:1172 (1995).
Lyttle et al., “Versatile Linker Chemistry for Synthesis of 3′-Modified DNA”,Chem. Abst., 128(18):314 (1997).
Asseline et al. “New Solid-Phase For Automated Synthesis of Oligonucleotides Containing An Amino-Alkyl Linker at Their 3′-End,”Tetrahedron Letters 31(1: 81-84 (1990).
Beattie et al., “123:112593k Synthesis and use of oligonucleotide libraries,”Chemical Abstracts 123: 1172 (1995).
Bonfils, E. and N.T. Thuong. “Solid Phase Synthesis of 5′, 3′Bifunctional Oligodeoxyribonucleotides Bearing a Masked Thiol Group at the 3′-End,”Tetrahedron Letters 32(26): 3053-3056 (1991).
Day et al., “Immobilization of polynucleotides on magnetic particles,”Biochem. J. 278: 735-740 (1991).
Debitsudo, A. “121:109581h Preparation of oligonucleotide monolayer,”Chemical Abstracts 121: 1163:1163 (1994).
Debitsudo, A. “121:83891g Preparation of nucleotide thioalkyl esters and monomolecular membrane,”Chemical Abstracts 121: 1166 (1994).
Debitsudo, A. “122:291447q Organic super-thin fim of oligonucleotide derivative and method for its preparation,”Chemical Abstracts 122: 1100 (1995).
Derwent No. 011716230, WPI Acc. No. 1998-133140/199813 for PCT Patent Application WO9805965 A1, “Identification of characteristics of eukaryotic cells—after covalent immobilisation on solid support,”.
Derwent No. 011999582, WPI Acc. No. 1998-416492/199836 for PCT Patent Application WO9834116 A1, “Isolation and determination of analyte—by capture on specific binding particles and concentration of these on second, limited binding surface before detection, used e.g. for detecting RNA,”.
Derwent No. 012012061, WPI Acc. No. 1998-428971/199837 for German Patent Application DE19731479 A, “Device for analysis of target chemicals has light emitting array—with chemical binder elements attached to array to capture target chemicals which change emitted light pattern accordingly,”.
Emmett, M.R. and R.M. Caprioli. “Micro-Electrospray Mass Spectrometry: Ultra-High-Sensitivity Analysis of Peptides and Proteins,”J. Am. Soc. Mass Spectrometry 5: 605-613 (1994).
Hofstadler et al. “Capillary Electrophoresis—Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Direct Analysis of Cellular Proteins,”Anal. Chem. 67: 1477-
Cantor Charles R.
Köster Hubert
Little Daniel P.
O'Donnell-Maloney Maryanne J.
Gakh Yelena G.
Grant Anderson LLP
Sequenom Inc.
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