Systems and methods for optical detection of lipofuscin...

Optics: eye examining – vision testing and correcting – Eye examining or testing instrument – Objective type

Reexamination Certificate

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C351S221000, C351S246000

Reexamination Certificate

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07914147

ABSTRACT:
A method for optical detection of lipofuscin concentrations in the retina is described. A subject's eye is exposed to a light source. Light emitted from the subject's eye is detected. Levels of lipofuscin are determined from the emitted light. A system for optical detection of lipofuscin in the retina is described. The system includes a light source to generate light. The system includes an optical detector in optical communication with the light source. The optical detector is configured to detect light emitted from a subject's eye. A computing device in electronic communication with the optical detector is included in the system to determine levels of lipofuscin from the emitted light.

REFERENCES:
patent: 6205354 (2001-03-01), Gellermann et al.
patent: 6315412 (2001-11-01), Snodderly et al.
patent: 2003/0004418 (2003-01-01), Marmorstein
patent: 2006/0082726 (2006-04-01), Suzuki
patent: 2006/0203194 (2006-09-01), Suzuki
patent: 2006/0244913 (2006-11-01), Gellerman et al.
J.R. Sparrow, C.A. Parish, M. Hashimoto, K. Nakanishi, “A2E, a Lipofuscin Fluorophore, in Human Retinal Pigmented Epithelial Cells in Culture,” Investigative Ophthalmology & Visual Science, Nov. 1999, vol. 40, No. 12, pp. 2988-2995.
L. Hong, J. Garguilo, L. Anzaldi, G.S. Edwards, R.J. Nemanich, J.D. Simon, “Age-dependent Photoionization Threshold of Melanosomes and Lipofuscin Isolated from Human Retinal Pigment Epithelium Cells,” Photochemistry and Photobiology, 2006, vol. 82, pp. 1475-1481.
F.C. Delori, D.G. Gorger, C.K. Dorey, “Age-Related Accumulation and Spatial Distribution of Lipofuscin in RPE of Normal Subjects,” Investigative Ophthalmology & Visual Science, Jul. 2001, Vo. 42, No. 8, pp. 1855-1866.
S. Hayasaka, “Aging Changes in Lipofuscin, Lysomoes and Melanin in the Macular Are of Human Retina and Choroid,” Japanese Journal of Ophthalmology, 1989, vol. 33, pp. 36-42.
F.C. Delori, M.R. Fleckner, D.G. Goger, J.J. Weiter, C.K. Dorey, “Autoflourescence Distribution Associated with Drusen in Age-Related Macular Degeneration,” Investigative Ophthalmology & Visual Science, Feb. 2000, vol. 41, No. 2, pp. 496-504.
D. Yin, “Biochemical Basis of Lipofuscin, Ceroid, and Age Pigment-like Flourophores,” Free Radical Biology & Medicine, 1996, vol. 21, No. 6, pp. 871-888.
R.F. Spaide, “Fundus Autofluorescence and Age-related Macular Degeneration,” Ophthalmology, Feb. 2003, vol. 110, No. 2, pp. 392-399.
F.C. Delori, C.K. Dorey, G. Staurenghi, O. Arend, D.G. Goger, J.J. Weiter, “In Vivo Flourescence of the Ocular Fundus Exhibits Retinal Pigment Epithelium Lipofuscin Characteristics,” Investigative Ophthalmology & Visual Science, Mar. 1995, vol. 36, No. 3, pp. 718-729.
M. Sharifzadeh, P.S. Bernstein, W. Gellermann, “Nonmydriatic Flourescence-based Quantitative Imagine of Human Macular Pigment Distributions,” Journal of the Optical Society of America, Oct. 2006, vol. 23, No. 10, pp. 2373-2387.
U. Wihlmark, A Wrigstad, K. Roberg, U.T. Brunk, S.E.G. Nilsson, “Lipofuscin formation in cultured retinal pigment epithelial cells exposed to photoreceptor outer segment material under different oxygen concentrations,” APMIS, 1996, vol. 104 pp. 265-271.
N. Lois, A.S. Halfyard, A.C. Bird, F.W. Fitzke, “Quantitative evaluation of fundus autoflourescence imaged “in vivo” in eyes with retinal disease,” British Journal of Ophthalmology, 2000, vol. 84, pp. 741-745.
F.C. Delori, “Spectrophotometer for noninvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus,” Applied Optics, Nov. 1994, vol. 33, No. 31, pp. 7439-7452.
J.R. Sparrow, K. Nakanishi, C.A. Parish, “The Lipofuscin Flourophore A2E Mediates Blue Light-Induced Damage to Retinal Pigmented Epithelial Cells,” Investigative Ophthalmology & Visual Science, Jun. 2000, vol. 41, No. 7, pp. 1981-1989.
International Search Report issued for International Patent Application No. PCT/US09/38297on May 27, 2009.
International Preliminary Report on Patentability issued for International Patent Application No. PCT/US2009/038297on Oct. 7, 2010.

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