Systems and methods for molecular recognition

Details Systems and methods for molecular recognition Systems and methods for molecular recognition

2007-06-01

2010-10-12

Chin, Christopher L (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

C436S524000, C436S815000, C436S901000

Reexamination Certificate

active

07811831

ABSTRACT:
Acoustic wave devices coated with a biolayer are described for the detection target bio-molecules. The acoustic wave device is connected in an oscillator circuit, and the frequency shift Δf resulting from a biomolecular event is recorded. Further described are the use of Rayleigh wave surface acoustic wave devices for vapor phase detection as well as quartz crystal microbalance devices for liquid phase measurements. A biofilm on the surface of the acoustic wave device comprises of a layer of antibodies raised against a specific target molecule or antigen. Signatures for detection events are presented in the form of frequency shifts Δf(t).

REFERENCES:
patent: 4735906 (1988-04-01), Bastiaans
patent: 5179028 (1993-01-01), Vali et al.
patent: 5770389 (1998-06-01), Ching et al.
Ngeh-Ngwainbi et al, “Parathion Antibodies on Piezoelectric Crystals”, J. Am. Chem. Soc., 1986, 108, 5444-5447.

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