Systems and methods for improving image-guided tissue ablation

Details Systems and methods for improving image-guided tissue ablation Systems and methods for improving image-guided tissue ablation

2005-03-31

2010-11-16

Lucchesi, Nicholas D (Department: 3763)

Surgery

Means for introducing or removing material from body for...

With means for cutting, scarifying, or vibrating tissue

C606S020000

Reexamination Certificate

active

07833187

ABSTRACT:
The cryosurgical kit and method of use relates to the combined use of biodegradable, imageable, drug(s) carriers, vectors or microcapsules deposited into a target tissue region inside a body and the controlled cooling of the target tissue region. A minimally invasive method of treatment that applies a cooling device to a selected tissue region, uses a vibrating resonant frequency delivery device to inject drug(s) carriers (microcapsules) containing therapeutic and contrast agents into tissue region(s) submitted to cooling temperatures, successive real-time imaging of the microcapsule deposition and later detection of the progressive degradation of microcapsules with ultrasound imaging which provides estimation of sustained release rates and for planning re-dosing regimens. The thermosensitive microcapsules preferably contain ethiodol, a contrast agent for Ultrasound and/or X-Ray imaging, and cytotoxic drug(s).

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