Systems and methods for identifying organ transplant risk

Details Systems and methods for identifying organ transplant risk Systems and methods for identifying organ transplant risk

2007-07-17

2007-07-17

Tate, Christopher R. (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

10313807

ABSTRACT:
The present invention relates to methods of diagnosing and predicting organ transplant rejection. In particular, the present invention relates to the detection and prediction of kidney transplant rejection by detection of CXCR3 and CCL chemokines in urine. The present invention provides improved methods of diagnosing organ rejection and determining the efficacy of anti-rejection drugs.

REFERENCES:
patent: 5484707 (1996-01-01), Goldblum et al.
patent: 2005/0112688 (2005-05-01), Hu et al.
patent: 2005/0158801 (2005-07-01), Hu et al.
patent: WO01/78708 (2001-10-01), None
patent: WO03/098185 (2003-11-01), None
patent: WO2005/012907 (2005-01-01), None
patent: WO2005/002416 (2005-10-01), None
Sibbring et al, “Localization fo C-X-C and C—C chemokines to renal tubular epithelial cells in human kidney transplants is not confined to acute cellular rejection”, Transplant Immunology, 1998, vol. 6, pp. 203-208.
Romagnani et al, “High expression of chemokines interferon-gamma-inducible protein of 10kDa (IP-10) , monokine induce by interferon-gamma (Mig) and of their receptor (CXCR2) in acute renal rejection”, Am. J. Transplant, 2001, vol. 1: S343, Abstract #825.
Hu et al., American J. Transpl., 2004; 4:432-437.
Segerer et al., J. Am. Soc. Nephrol., 11:152-176; 2000.
Nelson et al., Immunity, 14:377-386, Apr. 2001.
Romagnani et al., J Am Soc Nephrol. Dec. 1999;10(12):2518-26.
Gao et al., Transplantation. Oct. 15, 2001;72(7):1190-205.
RayBiotech, Inc., RayBio Cytokine Antibody Array web based product literature.
Upstate Cell Signaling Solutions, Beadlyte,Kits and Reagents for Luminex, Detection Systems web based product literature.
Hancock et al., J Exp Med. Nov. 20, 2000;192(10):1515-20.
Gerard et al., Nat Immunol. Feb. 2001;2(2):108-15.
Wong et al., Curr Opin Nephrol Hypertens. Nov. 2001;10(6):807-11 (abstract only).
Maier et al., Shock. Aug. 2000;14(2):187-92 (abstract only).
Poppas et al., Urology. Aug. 1998;52(2):268-75; discussion 275-6 (abstract only).
Rovin et al., Am J Kidney Dis. May 1996;27(5):640-6 (abstract only).
Olszyna et al., J Clin Immunol. Nov. 1999;19(6):399-405 (abstract only).
Kacprzyk, Pol Arch Med Wewn. Sep. 2002;108(3):837-42 (abstract only).
Sibbring et al., Transpl Immunol. Dec. 1998;6(4):203-8 (abstract only).
Pattison et al., Lancet. Jan. 22, 1994;343(8891):209-11 (abstract only).
Segerer et al., Kidney Int. Jul. 1999;56(1):52-64 (abstract only).
Grandaliano et al., Transplantation. Feb. 15, 1997;63(3):414-20 (abstract only).
Yun et al., Transplantation. Jun. 27, 2000;69(12):2515-24 (abstract only).
Segerer et al., Am. J. Kidney Dis. Mar. 2001, 37:518-31.
Hancock, J.Am. Soc. Nephrol. Mar. 2002, 13:821-824.
Afrouzian et al., J. Soc. Nephrol., Mar. 2002, 13:1199-1209.

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